Anisole

CAS: 100-66-3

Overview

Anisole (CAS 100-66-3 ), also known as phenyl methyl ether, is an aromatic ether used across fragrance, flavor, and specialty chemical manufacturing. Carrying FEMA 2097 status, it functions as a flavoring agent.

It serves as a key intermediate in synthesizing dyes, pharmaceuticals, and aroma chemicals. In fragrance and flavor formulation, it contributes anise-like and sweet floral notes to perfumes and personal care products.

Dye and pigment manufacturers use it as a chemical intermediate to produce methoxy-substituted aromatic compounds for printing inks and packaging colorants. It is also utilized in various food applications.

In catalysis, it acts as a solvent or substrate in Friedel-Crafts reactions and other electrophilic aromatic substitution processes relevant to fine chemical production. This makes it highly versatile for industrial use.

Its reactivity toward selective functionalization also makes it a precursor in synthesizing active pharmaceutical and agrochemical ingredients. This chemical is essential for high-precision synthesis in modern laboratories.

The product is supplied as a clear liquid in drum and IBC quantities, with bulk tanker options available for larger industrial volumes. Technical grade is the standard commercial offering for most buyers.

This grade meets purity specifications suitable for industrial synthesis and fragrance applications. Food-grade and flavor-compliant material is available for buyers requiring FEMA-recognized sourcing documentation.

Physical Properties

Melting Point	-37.3 °C
Boiling Point	155.5 °C @ Press: 760 Torr
Density	0.9956 g/cm³ @ Temp: 18 °C
Flash Point	125 °F
Appearance	Anisole is a colorless to yellowish liquid with an agreeable, aromatic, spicy-sweet odor.
Color	Clear colorless
Odor	phenol, anise odor
Form	Liquid
Water Solubility	1.6 g/L (20 ºC)
Vapor Pressure	10 mm Hg ( 42.2 °C)
Refractive Index	n 20/D 1.516(lit.)
Log P	2.62 at 30℃

Safety & Handling

Warning GHS02 GHS07 Hazard Statements H226 Flammable liquid and vapor H315 Causes skin irritation H319 Causes serious eye irritation H336 May cause drowsiness or dizziness Precautionary Statements P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P370+P378 Use … for extinction. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P403+P235 Store in a well-ventilated place. Keep cool. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code	29093000
UN Number	2222
ADR Class	3
Packing Group	III
Storage Class	3 - Flammable liquids
WGK (Germany)	2

Other Names

Industries

Printing & Packaging Personal Care & Cosmetics Food & Nutrition