Overview
Losartan potassium (CAS 124750-99-8 ) is an angiotensin II receptor antagonist active pharmaceutical ingredient used in the manufacture of antihypertensive drug products. Known under the reference brand Cozaar, it is a finished API supplied to generic drug manufacturers.
Generic pharmaceutical manufacturers use this material as the primary API in solid oral dosage forms, including tablets and film-coated tablets targeting hypertension and diabetic nephropathy indications. It is essential for cardiovascular therapies.
Contract development organizations source it for bioequivalence study batches and formulation development against the reference listed drug. It is also procured by compounding pharmacies requiring a documented API for patient-specific preparations.
Combination product developers incorporate it alongside diuretics such as hydrochlorothiazide in fixed-dose formulation programs. This versatility makes it a staple in modern pharmaceutical manufacturing and drug development cycles.
The material is supplied as a white to off-white crystalline powder. It is available in USP and EP ( Ph.Eur. ) grades, with ICH-compliant documentation packages including full DMF or ASMF references.
Regulated market buyers typically require these high-quality standards for their supply chains. Quantities range from research-scale to multi-kilogram commercial batches to meet various production needs.
GMP-certified manufacture is expected for finished dosage form supply chains to ensure safety and efficacy. This ensures that the final pharmaceutical products meet all necessary regulatory requirements for global distribution.
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Physical Properties
| Melting Point | 183.5-184.5 °C |
| Appearance | White to Off-White Crystalline Powder |
| Color | Off-white |
| Form | powder or crystals |
| Water Solubility | H2O: 2mg/mL, clear |
Safety & Handling
Danger GHS05 GHS07 GHS08 Hazard Statements H302 Harmful if swallowed H317 May cause an allergic skin reaction H318 Causes serious eye damage H319 Causes serious eye irritation H360 May damage fertility or the unborn child H361 Suspected of damaging fertility or the unborn child H362 May cause harm to breast-fed children H373 May causes damage to organs through prolonged or repeated exposure Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P263 Avoid contact during pregnancy and while nursing. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection. P317 Get emergency medical help. P318 IF exposed or concerned, get medical advice. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P333+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 2933290000 |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 124750-99-8
- EC Number
- 627-032-3
- Mol. Weight
- 461.0
- HS Code
- 2933290000
- Category
- Pharmaceutical Intermediates