Overview
2,4,5-Trimethyl-3-oxazoline (CAS 22694-96-8 ), also recognized in the flavor industry under FEMA No. 3525 , is a heterocyclic oxazoline compound used as a specialty aroma chemical and pharmaceutical building block.
Its roasted, nutty odor profile positions it as a functional ingredient in flavor formulation, while its reactive oxazoline ring makes it a useful intermediate in synthetic chemistry applications.
In flavor and fragrance manufacturing, it contributes characteristic roasted and cocoa-like notes to food products, beverages, and tobacco formulations where controlled dosing is critical to end-product quality.
Pharmaceutical and biotech researchers employ the oxazoline scaffold as a synthetic intermediate for constructing more complex heterocyclic APIs and research compounds for various clinical studies.
It also serves synthetic chemists in the preparation of chiral auxiliaries and ligands used in asymmetric catalysis workflows. Contract manufacturers sourcing building blocks evaluate it for its ring-opening reactivity.
2,4,5-Trimethyl-3-oxazoline is supplied as a liquid, typically at high purity levels suited to both flavor and pharmaceutical research applications. Standard offerings include technical-grade and research-grade material.
Documentation is aligned to FEMA-recognized flavor ingredient requirements where applicable. Packaging ranges from small quantities for laboratory use to larger volumes for industrial flavor production.
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Physical Properties
| Boiling Point | 45-47°C 12mm |
| Density | 0,919 g/cm 3 |
| Flash Point | 45-47°C/12mm |
| Appearance | Yellow-orange liquid; powerful, musty, nut-like odor. Soluble in alc, propylene glycol,water; insoluble in fixed oils. |
| Odor | at 0.10 % in dipropylene glycol. musty nutty vegetable cocoa nut skin bread crust phenolic woody |
| Form | liquid |
| Water Solubility | Soluble in alcohol, fixed oils. Insoluble in water. |
| Log P | 1.72 |
Safety & Handling
Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| Storage Class | 10 - Combustible liquids |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 22694-96-8
- EC Number
- 607-131-8
- Mol. Weight
- 113.16
- Category
- Heterocyclic Compounds