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Alcohols & Glycols

D-Propylene glycol

CAS: 4254-15-3

Overview

D-Propylene glycol (CAS 4254-15-3 ), also known as E490 , is the stereochemically pure (S)-enantiomer of propylene glycol, distinct from the racemic form used in most industrial applications.

It functions as a humectant, solvent, and stabilizer across personal care, pharmaceutical, and polymer manufacturing sectors. In cosmetic formulations, it is selected where enantiomeric purity influences sensory performance.

This includes premium moisturizers and serums where regulatory positioning is critical. Pharmaceutical manufacturers use it as a solvent and co-solvent in oral, topical, and injectable preparations where stereochemical specifications are required.

In polymer and resin systems, it acts as a chiral building block for cross-linking reactions and the synthesis of optically active polyesters. Coating and adhesive formulators incorporate it as a reactive intermediate.

This allows for controlled curing behavior and specific chain geometry that affect final film properties. The product is supplied as a clear, colorless liquid in bulk and intermediate packaging formats for industrial use.

Food-grade material is available under the E number designation, meeting relevant purity standards for use in regulated applications. Pharmaceutical-grade supply conforming to USP and Ph.Eur. specifications is accessible.

These grades are suitable for GMP-compliant manufacturing environments. Our supply chain ensures consistent quality and documentation for all technical, food, and pharmaceutical applications globally.

Contact us for supply of D-Propylene glycol

Physical Properties

Melting Point-59 °C
Boiling Point91-92 °C @ Press: 14 Torr
Density1.0364 g/cm³ @ Temp: 20 °C
Flash Point225 °F
AppearanceColorless to light yellow liqui
ColorClear colorless
FormLiquid
Water Solubilitysoluble
Refractive Indexn 20/D 1.432(lit.)

Safety & Handling

Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29053200
Storage Class10 - Combustible liquids
WGK (Germany)1

Other Names

(S)-propane-12-diol | (+)-12-Propanediol | (2S)-propane-12-diol | (s)-12-propanediol | E490

Related Products

Chemical Properties

CAS Number
4254-15-3
EC Number
610-039-0
Mol. Weight
76.09
HS Code
29053200

Industries

Documentation