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Flavors & Fragrances

Glycyrrhetinic acid

CAS: 471-53-4

Overview

Glycyrrhetinic acid (CAS 471-53-4 ), also known as uralenic acid, is a pentacyclic triterpenoid derived from licorice root extract. In personal care and cosmetics, it functions as a skin-conditioning active.

In flavoring applications, it contributes to the characteristic licorice taste profile of finished products. In cosmetic formulations, it is used in anti-inflammatory creams, serums, and spot-treatment products.

Formulators incorporate it into whitening and brightening preparations where it acts as a tyrosinase modulator. This helps to reduce the appearance of hyperpigmentation and redness in various skin types.

In the flavor industry, it is used as a flavoring agent and acidulant in confectionery and oral care products. It is also utilized in tobacco flavoring systems where a licorice character is required.

It appears in topical pharmaceutical preparations as a functional active in formulations addressing minor skin irritation. The material is supplied as a white to off-white crystalline powder for industrial use.

It is available in cosmetic-grade and pharmaceutical-grade specifications, with purity levels typically ranging from 95% to 98% by HPLC. These standards ensure high performance in sensitive applications.

Bulk quantities are offered in kilogram and multi-kilogram packaging to suit both development-scale and commercial production requirements. We ensure consistent quality for all global manufacturing needs.

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Physical Properties

Melting Point296 °C
Boiling Point687.4 °C
Density0.9967 (rough estimate)
Appearancewhite or greyish-white crystalline powder
ColorWhite to off-white
FormCrystalline Powder
Water SolubilitySOLUBLE IN ACETIC ACID
Vapor Pressure10-220Pa at 20-50℃
Refractive Index162 ° (C=1, MeOH)
Log P4.5 at 20℃

Safety & Handling

Warning GHS07 Hazard Statements H302 Harmful if swallowed H319 Causes serious eye irritation Precautionary Statements P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P330 Rinse mouth. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29189900
Storage Class11 - Combustible Solids
WGK (Germany)3

Other Names

Uralenic acid | Glycyrrhetic Acid | beta-Glycyrrhetic acid | b-Glycyrrhetic acid | alpha-Glycyrrhetinic acid | a-Glycyrrhetinic acid | 3b-Hydroxy-11-oxoolean-12-en-30-oic acid | 3b-Hydroxy-11-oxoolean-12-en-30-oate

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Chemical Properties

CAS Number
471-53-4
EC Number
207-444-6
Mol. Weight
470.7
HS Code
29189900

Industries

Documentation