Overview
Nordihydroguaiaretic acid (CAS 500-38-9 ), commonly identified in procurement as NDGA, is a naturally derived phenolic antioxidant extracted from the creosote bush. It functions as a potent lipid oxidation inhibitor and stabilizer across food, pharmaceutical, and cosmetic manufacturing.
In food processing, NDGA delays rancidity in fats, oils, and lipid-rich formulations where oxidative stability directly affects shelf life and product quality. Pharmaceutical formulators incorporate it as an antioxidant excipient to protect active ingredients.
It is used to protect lipid-based drug delivery systems from oxidative degradation during storage. In personal care and cosmetic manufacturing, it is used in creams, lotions, and suncare formulations for both antioxidant protection and UV stabilization.
Research and specialty chemical buyers also source NDGA as a reference standard or active compound in investigational formulations targeting oxidative stress pathways. This versatile compound is essential for maintaining the integrity of sensitive chemical structures.
Nordihydroguaiaretic acid is supplied as a fine crystalline powder. It is available in research-grade and technical-grade specifications, with high-purity grades typically exceeding ninety-eight percent purity for specialized use.
High-purity grades are offered for pharmaceutical and analytical applications. Packaging ranges from small quantities for laboratory and formulation development to bulk supply for industrial use, ensuring flexibility for various procurement needs.
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Physical Properties
| Melting Point | 185.5 °C |
| Boiling Point | 363.4°C (rough estimate) |
| Density | 1.0772 (rough estimate) |
| Appearance | light yellow crystalline solid |
| Color | White to off-white |
| Form | Powder |
| Water Solubility | slightly soluble |
| Refractive Index | 1.4230 (estimate) |
| Log P | 4.640 (est) |
Safety & Handling
Warning GHS07 Hazard Statements H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29072990 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 500-38-9
- EC Number
- 207-903-0
- Mol. Weight
- 302.4
- HS Code
- 29072990
- Category
- Flavors & Fragrances