Allyl bromide

CAS: 106-95-6

Overview

Allyl bromide (CAS 106-95-6 ) is a reactive alkylating agent used primarily as a chemical building block in pharmaceutical synthesis and specialty chemical manufacturing. Known commercially as 3-bromopropene, it introduces the allyl group into target molecules.

This process occurs through nucleophilic substitution reactions, enabling the construction of complex active pharmaceutical ingredients and fine chemicals. In pharmaceutical manufacturing, it serves as a key intermediate in synthesizing APIs.

This is particularly useful where allylation of nitrogen, oxygen, or sulfur nucleophiles is required. Biotechnology and life sciences researchers use it to functionalize biomolecules and synthesize allylated nucleosides or amino acid derivatives.

These materials are often used for research-scale production. The compound also supports the manufacture of agrochemical intermediates and specialty monomers where controlled allyl group incorporation is critical to the target structure.

Quaternary ammonium biocides with allyl functionality are produced using this substance as the alkylating precursor. The product is supplied as a liquid, typically in stabilized form to prevent premature polymerization during storage.

It is available in technical and high-purity grades to meet the requirements of pharmaceutical intermediate synthesis and research applications. This ensures compatibility with various industrial and laboratory protocols.

Standard packaging ranges from small laboratory quantities through to bulk drum supply for industrial-scale production. All batches are tested to ensure they meet rigorous internal quality standards and customer specifications.

Physical Properties

Melting Point	-119 °C
Boiling Point	71.3 °C @ Press: 760 Torr
Density	1.398 g/cm³ @ Temp: 20 °C
Flash Point	28 °F
Appearance	Allyl bromide is a highly flammable, colorless to light yellow liquid with an unpleasant, pungent odor.
Color	Clear colorless to slightly colored
Odor	unpleasant
Form	Liquid
Water Solubility	insoluble
Vapor Pressure	18.66kPa at 25℃
Refractive Index	n 20/D 1.469(lit.)
Log P	1.79

Safety & Handling

Danger GHS02 GHS05 GHS06 GHS07 GHS08 GHS09 Hazard Statements H225 Highly Flammable liquid and vapor H300 Fatal if swallowed H301 Toxic if swallowed H310 Fatal in contact with skin H314 Causes severe skin burns and eye damage H315 Causes skin irritation H318 Causes serious eye damage H319 Causes serious eye irritation H330 Fatal if inhaled H331 Toxic if inhaled H335 May cause respiratory irritation H340 May cause genetic defects H350 May cause cancer H400 Very toxic to aquatic life Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P262 Do not get in eyes, on skin, or on clothing. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P284 In case of inadequate ventilation wear respiratory protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P318 IF exposed or concerned, get medical advice. P319 Get medical advice/attention if you feel unwell. P320 Specific treatment is urgent (see … on this label). P321 Specific treatment (see … on this label). P330 Rinse mouth. P363 Wash contaminated clothing before reuse. P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P316 Get emergency medical help immediately. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P362+P364 Take off contaminated clothing and wash it before reuse. P370+P378 Use … for extinction. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P403+P235 Store in a well-ventilated place. Keep cool. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code	29033036
UN Number	1099
ADR Class	3
Packing Group	I
Storage Class	3 - Flammable liquids
WGK (Germany)	2

Other Names

Industries

Pharmaceuticals & Healthcare Biotechnology & Life Sciences