Overview
Alpha lipoic acid (CAS 1077-28-7 ) is a sulfur-containing antioxidant compound used across pharmaceutical, nutraceutical, and cosmetic manufacturing. It functions primarily as an antioxidant and cellular cofactor.
The material is used in both finished dosage forms and active ingredient formulations. In nutraceuticals and dietary supplements, it is formulated into capsules, tablets, and functional foods targeting metabolic support.
Cosmetic formulators incorporate it into anti-aging creams and serums where its antioxidant activity supports oxidative stability. Its skin-conditioning performance makes it a versatile choice for high-end topical applications.
Pharmaceutical manufacturers use it as an active ingredient in intravenous and oral preparations. This is common in markets where it holds drug status for specific neuropathic indications and therapeutic uses.
In food-grade applications, it is evaluated as an antioxidant stabilizer in fortified products and functional beverage systems. It helps maintain the integrity of complex formulations during the manufacturing process.
The product is supplied as a fine crystalline yellow powder. Standard grades include pharmaceutical-grade material meeting USP and Ph. Eur. specifications for global compliance and safety.
Food-grade and cosmetic-grade options are also available for non-pharmaceutical applications. Bulk quantities are provided for industrial-scale formulation to meet the demands of large-scale production facilities.
R-alpha lipoic acid is also available as a distinct enantiomer-specific grade for premium supplement applications. This specialized version offers targeted benefits for manufacturers seeking high-potency ingredients.
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Physical Properties
| Melting Point | 60-61 °C |
| Boiling Point | 160-165 °C |
| Density | 1.2888 (rough estimate) |
| Flash Point | 160-165°C |
| Appearance | Light-Yellow Solid |
| Color | Yellow |
| Form | Crystals or Crystalline Powder |
| Water Solubility | 0.9 g/L (20 ºC) |
| Refractive Index | 1.5200 (estimate) |
| Log P | 2.530 (est) |
Safety & Handling
Warning GHS07 GHS09 Hazard Statements H302 Harmful if swallowed H315 Causes skin irritation H317 May cause an allergic skin reaction H319 Causes serious eye irritation H335 May cause respiratory irritation H411 Toxic to aquatic life with long lasting effects H412 Harmful to aquatic life with long lasting effects Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P333+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29349900 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 1077-28-7
- EC Number
- 214-071-2
- Mol. Weight
- 206.3
- HS Code
- 29349900
- Category
- Amino Acids & Peptides