Overview
N,N,N',N'-Tetramethylethylenediamine (CAS 110-18-9 ), commercially known as TMEDA or TEMED, is a chelating diamine used as a ligand and catalyst activator across organometallic chemistry, polymer production, and life sciences.
It coordinates strongly with metal ions and alkyllithium reagents, enabling controlled reactivity in synthetic and industrial processes. In organolithium chemistry, TMEDA activates n-BuLi and similar reagents by breaking aggregates.
This improves reaction selectivity in pharmaceutical intermediate synthesis. Polymer manufacturers use it as an accelerator in acrylamide gel polymerization, most notably in PAGE gel systems for electrophoresis in biotech and diagnostic workflows.
In coordination chemistry and catalyst preparation, it acts as a bidentate ligand to stabilize metal complexes used in polymerization and fine chemical production. Specialty resin and rubber producers also employ it as a tertiary amine catalyst.
This helps to drive urethane and epoxy cure reactions. TMEDA is supplied as a colorless to pale yellow liquid, typically at 99%+ purity for synthesis-grade applications. Electrophoresis-grade material is available for life science users.
This material is designed to meet the tighter purity requirements of diagnostic end users. Bulk quantities are offered in drums and IBCs for industrial buyers, with smaller packaging available for laboratory and pharmaceutical procurement.
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Physical Properties
| Melting Point | -55 °C |
| Boiling Point | 121 °C |
| Density | 0.7765 g/cm³ @ Temp: 20 °C |
| Flash Point | 50 °F |
| Appearance | Colorless to slightly yellow liquid |
| Color | Clear colorless to slightly yellow |
| Odor | Amine like |
| Form | Liquid |
| Water Solubility | miscible |
| Vapor Pressure | 21 hPa (20 °C) |
| Refractive Index | n 20/D 1.4179(lit.) |
| pH | 8.0-8.5 (0.1g/l, H2O, 20℃) |
| Log P | -0.13 at 20.2℃ |
Safety & Handling
Danger GHS02 GHS05 GHS07 GHS06 GHS09 GHS08 Hazard Statements H225 Highly Flammable liquid and vapor H302 Harmful if swallowed H312 Harmful in contact with skin H314 Causes severe skin burns and eye damage H318 Causes serious eye damage H331 Toxic if inhaled H332 Harmful if inhaled H370 Causes damage to organs H411 Toxic to aquatic life with long lasting effects H302+H332 Harmful if swallowed or if inhaled Precautionary Statements P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P321 Specific treatment (see … on this label). P330 Rinse mouth. P363 Wash contaminated clothing before reuse. P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P308+P316 Get emergency medical help immediately. P362+P364 Take off contaminated clothing and wash it before reuse. P370+P378 Use … for extinction. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P403+P235 Store in a well-ventilated place. Keep cool. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29212900 |
| UN Number | 2372 |
| ADR Class | 3 |
| Packing Group | II |
| Storage Class | 3 - Flammable liquids |
| WGK (Germany) | 1 |
Other Names
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Chemical Properties
- CAS Number
- 110-18-9
- EC Number
- 203-744-6
- Mol. Weight
- 116.20
- HS Code
- 29212900
- Category
- Pigments & Colorants