Overview
Pioglitazone (CAS 111025-46-8 ) is an oral antidiabetic active pharmaceutical ingredient belonging to the thiazolidinedione class. It functions as an insulin sensitizer, targeting peripheral tissue resistance in the management of type 2 diabetes mellitus.
Pharmaceutical manufacturers source it as a finished API for solid dosage form development. Pioglitazone is the active ingredient in tablet formulations for type 2 diabetes, where it reduces insulin resistance in muscle and adipose tissue.
It works without stimulating pancreatic insulin secretion. Generic drug manufacturers use it as the primary API in both monotherapy and fixed-dose combination tablets alongside metformin or glimepiride for patient care.
Pharmaceutical intermediates suppliers also supply it to support synthesis research and formulation development pipelines targeting metabolic disease indications. This supports the growth of the global pharmaceutical market.
Contract development and manufacturing organizations (CDMOs) source it for bioequivalence study batches and commercial-scale tablet production. Pioglitazone is supplied as a white to off-white crystalline powder for industrial use.
It is available in pharmaceutical-grade specifications, including USP and Ph.Eur. compliant material. The hydrochloride salt form is the predominant commercial grade used in finished dosage manufacturing.
Bulk API is typically offered in kilogram to multi-kilogram quantities with full regulatory documentation support. This includes CoA, DMF references, and ICH-compliant impurity profiling for quality assurance.
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Physical Properties
| Melting Point | 183-184 °C |
| Boiling Point | 575.4±45.0 °C(Predicted) |
| Density | 1.260±0.06 g/cm3(Predicted) |
| Color | White to Off-White |
| Form | White to off-white solid. |
Safety & Handling
Warning GHS07 GHS08 Hazard Statements H302 Harmful if swallowed H312 Harmful in contact with skin H315 Causes skin irritation H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation H351 Suspected of causing cancer H302+H312+H332 Harmful if swallowed, in contact with skin or if inhaled Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P317 Get emergency medical help. P318 IF exposed or concerned, get medical advice. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Other Names
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Chemical Properties
- CAS Number
- 111025-46-8
- EC Number
- 601-029-7
- Mol. Weight
- 356.4
- Category
- UV Absorbers & Stabilizers