Overview
Aminomethyl propanediol ( CAS 115-69-5 ), commonly abbreviated as AMPD, is a multifunctional amino alcohol used across personal care, pharmaceutical, and industrial coating formulations.
It acts primarily as a pH buffer and neutralizing agent, adjusting and stabilizing formulation pH without introducing unwanted ionic species into the final chemical mixture.
In personal care and cosmetic formulations, AMPD neutralizes carbomer and acrylate polymers to build viscosity in creams, lotions, and gels for consumer use.
Pharmaceutical manufacturers use it as a buffering agent in topical preparations where controlled pH stability is critical to product shelf life and overall efficacy.
In waterborne coatings and adhesives, it functions as a neutralizer for resin systems, improving dispersion stability and film formation during the manufacturing process.
Its secondary hydroxyl groups also support moisture retention in formulations where humectancy is a secondary performance requirement alongside precise pH control.
AMPD is supplied as a white crystalline solid or as an aqueous solution, with pharmaceutical-grade material available to USP and BP specifications.
Standard commercial grades include technical and cosmetic grades, with packaging typically ranging from small drums to bulk quantities suited to industrial procurement volumes.
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Physical Properties
| Melting Point | 110 °C |
| Boiling Point | 143-145 °C @ Press: 10 Torr |
| Density | 1.0509 (estimate) |
| Flash Point | >100°C |
| Appearance | white powder |
| Color | White |
| Form | Crystalline Powder |
| Water Solubility | 2500 g/L (20 ºC) |
| Vapor Pressure | ~10 mm Hg ( 152 °C) |
| Refractive Index | 1.4754 (estimate) |
| pH | 10.0-12.0 (20℃, 0.5M in H2O) |
| Log P | -1.31 at 22℃ |
Safety & Handling
Danger GHS05 GHS07 Hazard Statements H315 Causes skin irritation H318 Causes serious eye damage H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P317 Get emergency medical help. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29221980 |
| UN Number | 3259 |
| ADR Class | 8 |
| Packing Group | II |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 1 |
Other Names
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Chemical Properties
- CAS Number
- 115-69-5
- EC Number
- 204-100-7
- Mol. Weight
- 105.14
- HS Code
- 29221980
- Category
- Alcohols & Glycols