Overview
N-Acetylneuraminic acid (CAS 131-48-6 ), commercially recognized under the abbreviations NeuAc, Neu5Ac, and NANA, is the predominant sialic acid found in mammalian biology. It is a critical building block in glycan chemistry.
It functions as a bioactive reference compound, surface modification agent, and functional ingredient across pharmaceutical, cosmetic, and biotechnology supply chains. In pharmaceutical and biotech manufacturing, Neu5Ac serves as a key substrate.
It is used as an analytical reference for sialylation studies, glycoprotein characterization, and enzyme assay development. Cosmetic formulators incorporate it into premium skincare products for its moisture-retention properties.
It plays a vital role in supporting skin barrier function at the cellular level. In food and nutrition, it is used as a bioactive ingredient in infant formula and functional food products targeting cognitive and immune health.
Biotechnology applications include its use as a precursor in the enzymatic or chemical synthesis of sialylated oligosaccharides and therapeutic glycoconjugates. This versatile compound is essential for modern research.
N-Acetylneuraminic acid is supplied as a white to off-white crystalline powder. It is available in research-grade and high-purity pharmaceutical-grade specifications, with purity levels typically at 95% or above.
GMP -compliant material is available for regulated applications. Packaging ranges from small laboratory quantities to bulk orders suited for industrial formulation and large-scale manufacturing needs.
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Physical Properties
| Melting Point | 182-184 °C |
| Boiling Point | 449.56°C (rough estimate) |
| Density | 1.3580 (rough estimate) |
| Appearance | Crystalline |
| Color | White to Off-White |
| Form | synthetic, crystalline |
| Water Solubility | 50 g/L (20 ºC) |
| Refractive Index | -32 ° (C=1, H2O) |
| Log P | -1.897 (est) |
Safety & Handling
Warning GHS07 Hazard Statements H319 H319 Precautionary Statements P280 P280 P264+P265 P264+P265 P337+P317 P337+P317 P305+P351+P338 P305+P351+P338
Trade & Regulatory
| HS Code | 29329900 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 131-48-6
- EC Number
- 205-023-1
- Mol. Weight
- 309.27
- HS Code
- 29329900
- Category
- Amino Acids & Peptides