Overview
Nicotinic acid (CAS 59-67-6 ), also known commercially as E375 and Niacin, is a water-soluble B-vitamin (B3) used across food, pharmaceutical, and personal care manufacturing. It functions as a nutrient fortifier, acidulant, and catalyst precursor depending on the application sector.
In food and beverage manufacturing, nicotinic acid is approved for flour and cereal fortification, restoring B-vitamin content lost during processing. Pharmaceutical producers use it as an active ingredient in vitamin B3 supplements and as a precursor in the synthesis of nicotinamide.
In personal care formulations, it supports skin-conditioning actives, particularly in products targeting uneven tone and barrier function. Specialty chemical manufacturers also employ it as a ligand or precursor in catalyst systems for organic synthesis processes.
Nicotinic acid is supplied as a white crystalline powder. Standard grades include USP , BP , Ph. Eur. , and food-grade specifications, with food-grade material conforming to purity requirements for direct food contact applications.
FCC -grade material is available for North American food and dietary supplement markets. This ensures compliance with strict safety standards across various global jurisdictions and industrial requirements for high-purity chemical sourcing.
The material is also available in EP and Ph.Eur. compliant forms to meet European pharmaceutical standards. These certifications guarantee the chemical integrity and consistency required for sensitive manufacturing environments and large-scale production.
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Physical Properties
| Melting Point | 236.6 °C |
| Boiling Point | 279-305 °C |
| Density | 1.473 g/cm³ @ Temp: 25 °C |
| Flash Point | 193°C |
| Appearance | White powder |
| Color | White to off-white |
| Odor | odorless to sl. odor, sour taste |
| Form | Powder |
| Water Solubility | 1-5 g/100 mL at 17 ºC |
| Refractive Index | 1.5423 (estimate) |
| pH | 2.7 (18g/l, H2O, 20℃) |
| Log P | 0.360 |
Safety & Handling
Warning GHS07 Hazard Statements H319 Causes serious eye irritation H402 Harmful to aquatic life Precautionary Statements P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29362990 |
| UN Number | 1230 |
| Packing Group | II |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 1 |
Other Names
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Chemical Properties
- CAS Number
- 59-67-6
- EC Number
- 200-441-0
- Mol. Weight
- 123.11
- HS Code
- 29362990
- Category
- Catalysts & Catalyst Precursors