Overview
Borane dimethyl sulfide complex (CAS 13292-87-0 ), commonly abbreviated as BMS, is a stabilized borane reagent used as a selective reducing agent in organic synthesis. Unlike unstabilized borane, BMS offers improved handling characteristics.
These features make it practical for large-scale pharmaceutical manufacturing and complex chemical processing. BMS is the reagent of choice for reducing carboxylic acids, amides, and oximes to their corresponding alcohols and amines.
In active pharmaceutical ingredient (API) synthesis, it is used in asymmetric hydroboration reactions. It is often paired with chiral auxiliaries to produce enantiomerically enriched intermediates for various drug candidates.
In agrochemical manufacturing, BMS supports the synthesis of herbicide and fungicide intermediates where controlled selectivity is critical. This ensures high yields and purity during the production of specialized crop protection chemicals.
Biotechnology researchers also employ it in the preparation of boronated compounds for boron neutron capture therapy (BNCT) research. It is further utilized in the development of labeled biochemical probes for diagnostic use.
Borane dimethyl sulfide complex is supplied as a liquid, typically as a neat reagent or in solution with tetrahydrofuran (THF). Standard concentrations of 2M and 10M in THF are commonly available for laboratory use.
Material is typically offered at reagent and synthesis grades to meet diverse industrial needs. High-purity specifications are available to meet strict pharmaceutical intermediate requirements and regulatory standards.
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Physical Properties
| Melting Point | -40--37°C |
| Boiling Point | ~34 °C |
| Density | 1.287 g/mL at 25 °C |
| Flash Point | 65 °F |
| Appearance | CLEAR COLOURLESS SOLUTION |
| Color | Colorless to pale yellow |
| Form | Solution |
| Water Solubility | reacts |
| Refractive Index | 1.4570 |
Safety & Handling
Danger GHS02 GHS05 GHS06 GHS07 GHS08 Hazard Statements H225 Highly Flammable liquid and vapor H260 In contact with water releases flammable gases which may ignite spontaneously H301 Toxic if swallowed H311 Toxic in contact with skin H315 Causes skin irritation H318 Causes serious eye damage H335 May cause respiratory irritation H360 May damage fertility or the unborn child H412 Harmful to aquatic life with long lasting effects H301+H311 Toxic if swallowed or in contact with skin Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P223 Do not allow contact with water. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P262 Do not get in eyes, on skin, or on clothing. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P318 IF exposed or concerned, get medical advice. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P231+P232 Handle and store contents under inert gas/… . P264+P265 Wash … thoroughly after handling. P301+P316 Get emergency medical help immediately. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P362+P364 Take off contaminated clothing and wash it before reuse. P370+P378 Use … for extinction. P402+P404 Store in a dry place. Store in a closed container. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P403+P235 Store in a well-ventilated place. Keep cool. P302+P335+P334 IF ON SKIN: Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29309090 |
| UN Number | 3399 |
| ADR Class | 4.3 |
| Packing Group | I |
| Storage Class | 4.3 - Hazardous materials which set free flammable gases upon contact with water |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 13292-87-0
- EC Number
- 236-313-6
- Mol. Weight
- 72.95
- HS Code
- 29309090
- Category
- Organometallic Compounds