Overview
Diethylphenylamine-borane (CAS 13289-97-9 ), also known as N,N-diethylanilineborane, is a selective organoboron reducing agent used in synthetic chemistry and pharmaceutical manufacturing. It delivers controlled hydride reduction under mild conditions.
This reagent offers greater selectivity than many conventional borohydride reagents. In pharmaceutical intermediate synthesis, it reduces imines, oximes, and carbonyl compounds with high chemoselectivity.
It supports the production of chiral amines and active pharmaceutical ingredient precursors. Industrial cleaning and surface treatment formulations use it as a catalyst or initiator in polymerization systems.
In biotechnology research, it supports reductive amination protocols for labeling, conjugation, and biomolecule modification workflows. It also functions as a catalyst precursor in organometallic chemistry.
Its amine-borane structure enables activation under specific reaction conditions. Diethylphenylamine-borane is typically supplied as a liquid or low-melting solid, depending on purity and handling conditions.
It is available in research and commercial quantities, with technical and high-purity grades suited to pharmaceutical and specialty chemical applications. Packaging ranges from small-scale laboratory quantities.
Bulk supply is available for process-scale synthesis. The material is handled according to strict safety protocols to ensure stability and performance in sensitive chemical transformations and industrial processes.
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Physical Properties
| Melting Point | −30-−27 °C(lit.) |
| Density | 0.917 g/mL at 25 °C(lit.) |
| Flash Point | 70 °F |
| Appearance | clear colorless to amber liquid |
| Color | Clear colorless to yellow |
| Form | Liquid |
| Water Solubility | MAY DECOMPOSE |
| Refractive Index | 1.5245-1.5265 |
Safety & Handling
Danger GHS02 GHS06 GHS08 GHS09 Hazard Statements H225 Highly Flammable liquid and vapor H260 In contact with water releases flammable gases which may ignite spontaneously H261 In contact with water releases flammable gas H301 Toxic if swallowed H311 Toxic in contact with skin H330 Fatal if inhaled H373 May causes damage to organs through prolonged or repeated exposure H411 Toxic to aquatic life with long lasting effects Precautionary Statements P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P223 Do not allow contact with water. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P262 Do not get in eyes, on skin, or on clothing. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P284 In case of inadequate ventilation wear respiratory protection. P316 Get emergency medical help immediately. P319 Get medical advice/attention if you feel unwell. P320 Specific treatment is urgent (see … on this label). P321 Specific treatment (see … on this label). P330 Rinse mouth. P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P231+P232 Handle and store contents under inert gas/… . P301+P316 Get emergency medical help immediately. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P370+P378 Use … for extinction. P402+P404 Store in a dry place. Store in a closed container. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P403+P235 Store in a well-ventilated place. Keep cool. P302+P335+P334 IF ON SKIN: Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
Trade & Regulatory
| HS Code | 29299090 |
| UN Number | 3398 |
| ADR Class | 4.3 |
| Packing Group | II |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 13289-97-9
- EC Number
- 236-305-2
- Mol. Weight
- 160.05
- HS Code
- 29299090
- Category
- Pharmaceutical Intermediates