Overview
Hexadecyltrimethoxysilane (CAS 16415-12-6 ), also known as Cetyl trimethoxysilane, is a long-chain alkylsilane used to chemically modify inorganic surfaces and impart hydrophobicity.
It bonds covalently to mineral substrates, enabling durable water repellency and improved compatibility between inorganic fillers and organic matrices. In coatings and sealants, it treats mineral fillers.
Commonly treated fillers include silica, calcium carbonate, and talc to improve dispersion and reduce moisture uptake in the final formulation. Adhesive and elastomer manufacturers use it as a coupling agent.
This silane strengthens the interface between polymer matrices and glass or silica-based reinforcements. In plastics compounding, surface-treated fillers processed with this silane deliver better mechanical performance.
The material also helps in reducing agglomeration during processing. Personal care formulators apply it to powder pigments and mineral actives to convert hydrophilic surfaces to hydrophobic ones.
This application improves skin feel and water resistance in color cosmetics. The product is supplied as a clear to slightly yellow liquid and is available in technical grade with purity levels at 95% or higher.
Packaging ranges from small drums to bulk IBC containers, depending on supplier and volume requirements. This versatile chemical ensures high performance across various industrial and consumer applications.
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Physical Properties
| Melting Point | -1 °C |
| Boiling Point | 155 °C @ Press: 0.2 Torr |
| Density | 0.890 g/cm³ |
| Flash Point | 165°C |
| Color | Colorless to Almost colorless |
| Form | clear liquid |
| Water Solubility | 2μg/L at 20℃ |
| Vapor Pressure | 0Pa at 20℃ |
| Refractive Index | n 20/D 1.44 |
| Log P | 8.1 at 20℃ |
Safety & Handling
Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29319090 |
| Storage Class | 10 - Combustible liquids |
| WGK (Germany) | 1 |
Other Names
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Chemical Properties
- CAS Number
- 16415-12-6
- EC Number
- 240-464-3
- Mol. Weight
- 346.6
- HS Code
- 29319090
- Category
- Silicones & Silicates