Overview
9-Borabicyclononane (CAS 280-64-8 ), commercially supplied as its stable dimer 9-borabicyclo[3.3.1]nonane dimer, is a selective hydroboration reagent used in synthetic chemistry.
It enables precise, stereoselective addition of boron to alkenes, making it a preferred reagent for building chiral intermediates in complex molecule synthesis for various industries.
In pharmaceutical manufacturing, it is used to produce enantiomerically enriched intermediates for active pharmaceutical ingredients where stereochemical control is critical for the final product.
Suzuki–Miyaura cross-coupling reactions rely on it as a boron source to form carbon–carbon bonds in the synthesis of drug candidates and fine chemicals for global distribution.
Biotechnology and life sciences researchers use it in the preparation of labeled compounds and probe molecules for biological assays and advanced diagnostic testing procedures.
Industrial cleaning and specialty chemical formulators source it as a catalyst precursor in boron-mediated reaction sequences requiring high regioselectivity and consistent chemical performance.
9-Borabicyclononane is supplied as a solid dimer or as stabilized solutions in tetrahydrofuran or other anhydrous solvents. Standard concentrations for solution grades are typically 0.5 M and 1.0 M.
Material is available at research, pilot, and commercial scale, with specifications aligned to pharmaceutical-grade synthetic reagent requirements and rigorous quality control protocols.
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Physical Properties
| Melting Point | 140-142 °C |
| Boiling Point | 68-70 °C |
| Density | 0.894 g/mL at 25 °C |
| Flash Point | 1 °F |
| Appearance | WHITE CRYSTALLINE POWDER |
| Form | liquid |
| Water Solubility | reacts |
Safety & Handling
Danger GHS02 GHS05 Hazard Statements H250 Catches fire spontaneously if exposed to air H260 In contact with water releases flammable gases which may ignite spontaneously H314 Causes severe skin burns and eye damage Precautionary Statements P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P222 Do not allow contact with air. P223 Do not allow contact with water. P231 Handle and store contents under inert gas/… . P233 Keep container tightly closed. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P321 Specific treatment (see … on this label). P363 Wash contaminated clothing before reuse. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P231+P232 Handle and store contents under inert gas/… . P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P370+P378 Use … for extinction. P402+P404 Store in a dry place. Store in a closed container. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P335+P334 IF ON SKIN: Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29319090 |
| UN Number | 3399 |
| ADR Class | 4.3 |
| Packing Group | I |
| Storage Class | 4.3 - Hazardous materials which set free flammable gases upon contact with water |
| WGK (Germany) | 3 |
Other Names
Related Products
Chemical Properties
- CAS Number
- 280-64-8
- EC Number
- 206-000-9
- Mol. Weight
- 122.02
- HS Code
- 29319090
- Category
- Pharmaceutical Intermediates