tert-butyl n-hydroxycarbamate

Tert-butyl n-hydroxycarbamate (CAS 36016-38-3 ), commonly sourced under the name N-Boc-hydroxylamine, is a protected hydroxylamine reagent used in pharmaceutical synthesis and specialty chemical manufacturing.

It provides a stable, handleable form of hydroxylamine functionality, enabling controlled introduction of the N–OH group into target molecules without the hazards associated with free hydroxylamine.

In pharmaceutical intermediate synthesis, it serves as a key building block for constructing isoxazolines, hydroxyurea derivatives, and other nitrogen-containing scaffolds found in active pharmaceutical ingredients.

Medicinal chemistry programs use it to install protected hydroxylamine groups during multi-step synthesis, with the Boc protecting group removed under standard acidic conditions at a late stage.

Catalyst development programs employ it as a precursor to nitroxide-based and N-oxyl catalysts used in oxidation reactions. Specialty formulation research has explored its biocidal activity.

Tert-butyl n-hydroxycarbamate is supplied as a white to off-white crystalline solid. It is available in research quantities through to multi-kilogram commercial lots for industrial use.

Purity grades typically range from 97% to 99%+ as confirmed by HPLC or titration. Supply is generally positioned for pharmaceutical and fine chemical use with documentation packages including CoA.

Spectral data is standard for GMP-adjacent procurement. This material is handled according to strict safety protocols to ensure stability and performance in sensitive chemical reactions.

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