Overview
Retinol (CAS 68-26-8 ), also marketed as Vitamin A1, is the bioavailable alcohol form of Vitamin A used across cosmetic, nutritional, and pharmaceutical manufacturing. It functions as a cell-renewal active in topical formulations.
In cosmetics, retinol is the primary active in anti-aging serums, night creams, and treatment moisturizers, where it drives skin cell turnover at concentrations typically ranging from 0.01% to 1%.
Nutritional supplement manufacturers incorporate it into softgel capsules, multivitamin tablets, and fortified powders to meet established dietary reference values. Food producers use it to fortify dairy products.
It is also utilized in infant formula and cooking oils, restoring vitamin content lost during processing. Pharmaceutical-grade retinol enters topical drug formulations and compounded preparations targeting dermatological indications.
Retinol is supplied as a crystalline powder or stabilized oil solution, with oil-based forms common for easier handling and formulation incorporation. Standard grades include USP , BP , and Ph. Eur.
These grades support pharmaceutical and nutraceutical compliance requirements. Food-grade material meeting FCC specifications is available for fortification applications and various industrial processes.
Encapsulated or beadlet forms are offered to improve stability during processing and shelf life. These specialized formats ensure the active ingredient remains potent throughout the manufacturing cycle.
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Physical Properties
| Melting Point | 62-64 °C |
| Boiling Point | 137-138 °C @ Press: 1 x 10-6 Torr |
| Density | 0.9933 (rough estimate) |
| Flash Point | -26 °C |
| Appearance | Yellow-Orange Powder |
| Color | yellow to orange |
| Form | crystalline |
| Water Solubility | Practically insoluble inwaterorglycerol; soluble in absolute alcohol,methanol,℃hloroform, ether, fats and oils. |
| Refractive Index | 1.641 |
| pH | 6.5-7.5 (20°C, 100g/L in H2O) |
| Log P | 5.680 |
Safety & Handling
Danger GHS07 GHS08 Hazard Statements H302 Harmful if swallowed H317 May cause an allergic skin reaction H319 Causes serious eye irritation H360 May damage fertility or the unborn child H413 May cause long lasting harmful effects to aquatic life Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P318 IF exposed or concerned, get medical advice. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P333+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29362100 |
| UN Number | 1208 |
| ADR Class | 3 |
| Packing Group | II |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 68-26-8
- EC Number
- 200-683-7
- Mol. Weight
- 286.5
- HS Code
- 29362100
- Category
- Pigments & Colorants