Overview
Cholecalciferol (CAS 67-97-0 ), also known as Vitamin D3, is the animal-derived form of vitamin D used across food fortification, dietary supplements, animal feed, and pharmaceutical manufacturing.
It supports calcium and phosphorus metabolism regulation, making it a critical active ingredient for bone health and nutritional product development in various industrial applications.
In food and beverage manufacturing, cholecalciferol is used to fortify dairy products, plant-based milks, cereals, and infant formula to meet established nutritional labeling standards.
Premix and supplement manufacturers incorporate it into softgels, tablets, and powdered blends where precise dosing and stability in oil-based carriers are required for the final product.
Animal feed producers use it to support skeletal development and egg production performance in poultry, swine, and aquaculture operations to ensure optimal livestock health and yield.
Pharmaceutical-grade cholecalciferol is also used as the active in prescription and OTC vitamin D3 formulations, including drops and oral solutions targeting deficiency treatment.
Cholecalciferol is supplied as an oily liquid concentrate, dry powder, or microencapsulated beadlet form to suit different manufacturing processes and stability requirements.
Recognized grades include USP , BP , Ph. Eur. , and food-grade specifications to meet regulatory requirements across pharmaceutical, nutraceutical, and feed markets.
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Physical Properties
| Melting Point | 84-85 °C |
| Boiling Point | 451.27°C (rough estimate) |
| Density | 0.939 g/cm³ |
| Flash Point | 14 °C |
| Appearance | Crystalline |
| Color | White |
| Odor | odorless |
| Form | powder |
| Water Solubility | <0.1 g/L (20 ºC) |
| Vapor Pressure | 2.0 x l0 -6 Pa (20 °C, est.) |
| Refractive Index | 1.5100 (estimate) |
| Log P | 9.085 (est) |
Safety & Handling
Danger GHS06 GHS08 Hazard Statements H300 Fatal if swallowed H301 Toxic if swallowed H310 Fatal in contact with skin H311 Toxic in contact with skin H330 Fatal if inhaled H360 May damage fertility or the unborn child H372 Causes damage to organs through prolonged or repeated exposure Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P262 Do not get in eyes, on skin, or on clothing. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P284 In case of inadequate ventilation wear respiratory protection. P316 Get emergency medical help immediately. P318 IF exposed or concerned, get medical advice. P319 Get medical advice/attention if you feel unwell. P320 Specific treatment is urgent (see … on this label). P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P301+P316 Get emergency medical help immediately. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Trade & Regulatory
| HS Code | 29362990 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| WGK (Germany) | 2 |
Other Names
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Chemical Properties
- CAS Number
- 67-97-0
- EC Number
- 200-673-2
- Mol. Weight
- 384.6
- HS Code
- 29362990
- Category
- Flavors & Fragrances