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Polymers & Resins

Hydroxypropyl methylcellulose

CAS: 9004-65-3

Overview

Hydroxypropyl methylcellulose (CAS 9004-65-3 ), commercially known as HPMC and approved as food additive E464 , is a cellulose-derived polymer used across pharmaceuticals, construction, food, and personal care.

It functions primarily as a thickener, binder, and film-former, controlling viscosity and water retention in a broad range of formulations. In pharmaceutical manufacturing, HPMC is a critical excipient for tablet coating.

It is used for controlled-release matrix systems and capsule shells, including vegetarian alternatives to gelatin. Tile adhesives, cement renders, and dry-mix mortars rely on it to extend open time.

This material improves workability on construction sites. Food manufacturers use E464 to stabilize emulsions, control texture in low-fat products, and prevent moisture migration in baked goods.

In personal care, it thickens shampoos, gels, and ophthalmic solutions while providing a smooth, non-tacky film on skin and hair. HPMC is supplied as a white to off-white powder in a range of viscosity grades.

It is typically characterized by methoxy and hydroxypropoxy substitution levels. Established grades include USP /NF, Ph.Eur. , BP , and food-grade ( FCC /E464-compliant) specifications to meet regulatory requirements.

These standards ensure safety across various global industries. Technical-grade material is also available for construction applications where pharmaceutical or food compliance is not required.

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Physical Properties

Melting Point202 °C
Density1.0 g/cm³ (solid)
Appearancewhite or slightly beige powder or a viscous solution
ColorWhite to cream
OdorOdorless
Formpowder
Water SolubilitySOLUBLE
pH5.0-8.0

Trade & Regulatory

HS Code39129000
Storage Class11 - Combustible Solids
WGK (Germany)1

Other Names

HPMC | Cellulose2-hydroxypropyl methyl ether | Hydroxypropyl methyl cellulose ether | Methocel X 2602 | Methyl hydroxypropyl cellulose | Cellulose hydroxypropyl methyl ether | E464

Related Products

Chemical Properties

CAS Number
9004-65-3
EC Number
618-389-6
Mol. Weight
-
HS Code
39129000

Industries

Documentation