Overview
Hydroxypropyl methylcellulose (CAS 9004-65-3 ), commercially known as HPMC and approved as food additive E464 , is a cellulose-derived polymer used across pharmaceuticals, construction, food, and personal care.
It functions primarily as a thickener, binder, and film-former, controlling viscosity and water retention in a broad range of formulations. In pharmaceutical manufacturing, HPMC is a critical excipient for tablet coating.
It is used for controlled-release matrix systems and capsule shells, including vegetarian alternatives to gelatin. Tile adhesives, cement renders, and dry-mix mortars rely on it to extend open time.
This material improves workability on construction sites. Food manufacturers use E464 to stabilize emulsions, control texture in low-fat products, and prevent moisture migration in baked goods.
In personal care, it thickens shampoos, gels, and ophthalmic solutions while providing a smooth, non-tacky film on skin and hair. HPMC is supplied as a white to off-white powder in a range of viscosity grades.
It is typically characterized by methoxy and hydroxypropoxy substitution levels. Established grades include USP /NF, Ph.Eur. , BP , and food-grade ( FCC /E464-compliant) specifications to meet regulatory requirements.
These standards ensure safety across various global industries. Technical-grade material is also available for construction applications where pharmaceutical or food compliance is not required.
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Physical Properties
| Melting Point | 202 °C |
| Density | 1.0 g/cm³ (solid) |
| Appearance | white or slightly beige powder or a viscous solution |
| Color | White to cream |
| Odor | Odorless |
| Form | powder |
| Water Solubility | SOLUBLE |
| pH | 5.0-8.0 |
Trade & Regulatory
| HS Code | 39129000 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 1 |
Other Names
Related Products
Chemical Properties
- CAS Number
- 9004-65-3
- EC Number
- 618-389-6
- Mol. Weight
- -
- HS Code
- 39129000
- Category
- Polymers & Resins