Overview
Solketal (CAS 100-79-8 ), also known as Glycerol dimethylketal, is a cyclic acetal derived from glycerol used as a solvent, carrier, and chemical intermediate across pharmaceutical, cosmetic, and polymer applications.
Its low toxicity profile and biodegradable character make it a preferred alternative to conventional solvents in formulations where regulatory compliance and sustainability drive sourcing decisions.
In pharmaceutical manufacturing, this compound functions as a solvent and carrier for active ingredients, improving solubility and stability in oral and topical drug formulations.
Cosmetic formulators incorporate it as a skin-conditioning carrier and co-solvent in serums, creams, and emulsions where clean-label positioning is a priority for the brand.
In polymer and resin chemistry, it acts as a reactive intermediate and crosslinking agent, particularly in the synthesis of specialty polyols and high-performance industrial coatings.
It also serves as a stabilizer in fuel blending applications, where it improves cold-flow properties and reduces oxidative degradation in modern biodiesel formulations.
The material is supplied as a clear liquid in drum and IBC quantities suited to industrial procurement. Pharmaceutical-grade material is available to meet USP and BP specifications.
Technical-grade product serves polymer and fuel applications. Purity levels typically range from 98% to 99%+ depending on the specific grade and the intended industrial end use.
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Physical Properties
| Melting Point | -26.4 °C |
| Boiling Point | 188 °C |
| Density | 1.06 g/cm³ |
| Flash Point | 176 °F |
| Appearance | clear colourless liquid |
| Color | Clear colorless |
| Form | Liquid |
| Water Solubility | miscible |
| Vapor Pressure | 34Pa at 20℃ |
| Refractive Index | n 20/D 1.434 |
| pH | 4.0-7.5 (H2O) |
| Log P | 0.3 at 20℃ |
Safety & Handling
Warning GHS07 GHS09 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H411 Toxic to aquatic life with long lasting effects Precautionary Statements P264 Wash … thoroughly after handling. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P321 Specific treatment (see … on this label). P391 Collect spillage. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29329970 |
| Storage Class | 10 - Combustible liquids |
| WGK (Germany) | 2 |
Other Names
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Chemical Properties
- CAS Number
- 100-79-8
- EC Number
- 202-888-7
- Mol. Weight
- 132.16
- HS Code
- 29329970
- Category
- Solvents