Overview
Propylamine (CAS 107-10-8 ) is a primary aliphatic amine used as a reactive intermediate and pH modifier across pharmaceutical, polymer, and flavor chemistry. With FEMA 4237 status, it is also recognized in flavor applications under regulated conditions.
Its reactivity toward carbonyl compounds, acids, and isocyanates makes it a building block for a broad range of synthesized end products. In pharmaceutical manufacturing, it serves as an intermediate in the synthesis of active ingredients.
It is particularly useful for antihistamines and cardiovascular compounds. Polymer producers use it as a curing agent and cross-linker for epoxy systems, where amine reactivity directly influences cure rate and final mechanical properties.
In flavor formulation, it contributes to specific aroma profiles at controlled concentrations under FEMA guidelines. Personal care chemists incorporate it as a pH buffer and neutralizing agent in formulations requiring precise alkalinity control.
Propylamine is supplied as a liquid, typically at high purity grades suited to pharmaceutical and industrial synthesis. Technical grade is standard for polymer and chemical manufacturing applications across various industries.
Pharmaceutical-grade material is available where API synthesis or regulated flavor use requires tighter specification and documentation. This ensures compliance with rigorous safety and quality standards for sensitive chemical processes.
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Physical Properties
| Melting Point | -83 °C |
| Boiling Point | 48-49 °C |
| Density | 0.719 g/cm³ @ Temp: 20 °C |
| Flash Point | −35 °F |
| Appearance | n-Propylamine is a water-white liquid with a strong irritating odor similar to that of ammonia |
| Color | Clear colorless to pale yellow |
| Odor | ammoniacal |
| Form | Liquid |
| Water Solubility | soluble |
| Vapor Pressure | 4.79 psi ( 20 °C) |
| Refractive Index | n 20/D 1.388(lit.) |
| pH | 12.6 (100g/l, H2O, 20℃) |
| Log P | 0.55 |
Safety & Handling
Danger GHS02 GHS05 GHS06 GHS07 Hazard Statements H225 Highly Flammable liquid and vapor H290 May be corrosive to metals H302 Harmful if swallowed H311 Toxic in contact with skin H314 Causes severe skin burns and eye damage H318 Causes serious eye damage H331 Toxic if inhaled H335 May cause respiratory irritation H412 Harmful to aquatic life with long lasting effects H311+H331 Toxic in contact with skin or if inhaled. Precautionary Statements P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P234 Keep only in original packaging. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P262 Do not get in eyes, on skin, or on clothing. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P363 Wash contaminated clothing before reuse. P390 Absorb spillage to prevent material damage. P405 Store locked up. P406 Store in a corrosion-resistant/… container with a resistant inner liner. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P370+P378 Use … for extinction. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P403+P235 Store in a well-ventilated place. Keep cool. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29211990 |
| UN Number | 1277 |
| ADR Class | 3 |
| Packing Group | II |
| Storage Class | 3 - Flammable liquids |
| WGK (Germany) | 1 |
Other Names
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Chemical Properties
- CAS Number
- 107-10-8
- EC Number
- 203-462-3
- Mol. Weight
- 59.11
- HS Code
- 29211990
- Category
- Amines