Overview
Hexafluoroisopropyl methyl ether (CAS 13171-18-1 ), also known as HFE-356mmz1, is a fluorinated ether solvent used in specialized pharmaceutical and chemical processing applications. Iso-indoklon is a recognized trade reference for this compound in anesthetic research contexts.
Its fluorinated structure delivers low surface tension and selective solvency, making it a candidate solvent where conventional options are unsuitable. In pharmaceutical manufacturing, it functions as a reaction solvent for fluorine-containing active pharmaceutical ingredient synthesis.
Its chemical inertness prevents unwanted side reactions during complex chemical processes. It has been investigated as an inhalation anesthetic agent, with historical research under the Iso-indoklon designation informing modern CNS-active compound development.
Formulators working with specialty coatings or fluoropolymer systems use it as a carrier solvent where precise solvency control is required. Its low reactivity also supports use as a cleaning and rinsing solvent in precision manufacturing environments.
This compound is particularly effective when handling sensitive pharmaceutical equipment that requires non-reactive cleaning agents. Hexafluoroisopropyl methyl ether is supplied as a clear liquid, typically in research and specialty chemical quantities.
It is available at high-purity grades suited to pharmaceutical research and synthesis applications. Packaging ranges from small laboratory quantities to bulk supply depending on supplier capability and end-use requirements for industrial applications.
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Physical Properties
| Boiling Point | 50.0-50.5 °C |
| Density | 1.39 |
| Flash Point | >93°C |
| Color | Colorless to Almost colorless |
| Form | Liquid:volatile |
| Vapor Pressure | 17.81-101.325kPa at 10-50.95℃ |
| Refractive Index | 1.284 |
| Log P | 1.807 at 25℃ and pH6-8 |
Safety & Handling
Danger GHS02 GHS07 Hazard Statements H225 Highly Flammable liquid and vapor H315 Causes skin irritation H319 Causes serious eye irritation Precautionary Statements P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P264 Wash … thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P321 Specific treatment (see … on this label). P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P370+P378 Use … for extinction. P403+P235 Store in a well-ventilated place. Keep cool. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 2909191800 |
| UN Number | 3334 |
Other Names
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Chemical Properties
- CAS Number
- 13171-18-1
- EC Number
- 603-501-8
- Mol. Weight
- 182.06
- HS Code
- 2909191800
- Category
- Solvents