Overview
Lamivudine (CAS 134678-17-4 ), also known by the abbreviation 3TC and supplied under the trade name Heptovir, is a nucleoside reverse transcriptase inhibitor used as an active pharmaceutical ingredient.
It is a core component in formulations targeting HIV and chronic hepatitis B, and is recognized globally as an essential API in both branded and generic pharmaceutical pipelines for global distribution.
Lamivudine is primarily used in the manufacture of oral solid dosage forms, such as tablets and film-coated tablets, for HIV treatment regimens often combined with other antiretroviral APIs in products.
Generic pharmaceutical manufacturers source it as a key API for hepatitis B antiviral therapies, where regulatory-grade purity is a critical procurement requirement for international safety standards.
It is also used by formulators developing pediatric oral solutions, requiring specific solubility-compatible grades. Contract development and manufacturing organizations source it as a synthesis intermediate.
Lamivudine is available as a white crystalline powder in pharmaceutical-grade specifications. Recognized grades include USP , BP , and Ph. Eur. , aligning with the requirements of regulated markets.
These standards ensure compliance in North America, Europe, and beyond. Supply is typically offered in kilogram to metric-ton quantities, with documentation packages supporting GMP-compliant procurement.
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Physical Properties
| Melting Point | 160-162 °C |
| Boiling Point | 475.4±55.0 °C(Predicted) |
| Density | 1.73±0.1 g/cm3(Predicted) |
| Flash Point | 9°C |
| Appearance | White Crystalline Powder |
| Color | white to beige |
| Form | powder |
| Water Solubility | 70g/L(temperature not stated) |
| Refractive Index | -142 ° (C=1, MeOH) |
Safety & Handling
Warning GHS07 GHS08 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation H361 Suspected of damaging fertility or the unborn child H373 May causes damage to organs through prolonged or repeated exposure Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P318 IF exposed or concerned, get medical advice. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29349900 |
| UN Number | 1230 |
| Packing Group | II |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 134678-17-4
- EC Number
- 603-844-3
- Mol. Weight
- 229.26
- HS Code
- 29349900
- Category
- Heterocyclic Compounds