Overview
Memantine hydrochloride (CAS 41100-52-1 ) is the salt form of memantine, an NMDA receptor antagonist active pharmaceutical ingredient used in the treatment of moderate-to-severe Alzheimer's disease.
Supplied as a finished API or pharmaceutical intermediate, it is a primary target for generic drug manufacturers and contract formulators sourcing for solid oral dosage development.
Generic pharmaceutical manufacturers use this material as the active ingredient in immediate-release and extended-release tablet formulations indicated for cognitive decline disorders.
Contract development organizations source it as a reference standard or bulk API for bioequivalence studies and formulation development against branded products in the marketplace.
It is also procured by compounding pharmacies requiring a documented API for patient-specific preparations. Research institutions source pharmaceutical-grade material for investigational use.
Memantine hydrochloride is available as a white crystalline powder in bulk quantities ranging from laboratory-scale to commercial API lots for global distribution and manufacturing.
Standard supply grades include USP , EP ( Ph. Eur. ), and in-house pharmaceutical grades with full ICH-compliant documentation packages for regulatory submission.
Certificates of Analysis, DMF references, and impurity profiles are standard documentation expectations for this material in regulated markets to ensure safety and compliance.
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Physical Properties
| Melting Point | 290-295 °C |
| Appearance | Crystalline Solid |
| Color | White |
| Form | Fine Powder |
| Water Solubility | Soluble in water (100mM) |
Safety & Handling
Warning GHS07 Hazard Statements H302 Harmful if swallowed H312 Harmful in contact with skin H315 Causes skin irritation H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation H336 May cause drowsiness or dizziness Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P317 Get emergency medical help. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29213000 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 3 |
Other Names
Related Products
Chemical Properties
- CAS Number
- 41100-52-1
- EC Number
- 255-219-6
- Mol. Weight
- 215.76
- HS Code
- 29213000
- Category
- Pharmaceutical Intermediates