Overview
Abacavir sulfate (CAS 188062-50-2 ), also referenced in procurement as abacavir hemisulfate or 1592U89 sulfate, is the salt form of abacavir used as the active pharmaceutical ingredient in antiretroviral drug manufacturing.
It functions as a nucleoside reverse transcriptase inhibitor (NRTI) incorporated into finished dosage forms targeting HIV treatment. The primary commercial application is in the manufacture of oral solid and liquid antiretroviral formulations.
These formulations include tablets, film-coated tablets, and oral solutions for HIV-1 treatment. It is used as a key API in fixed-dose combination products, where it is co-formulated alongside other antiretroviral agents.
Common co-formulations include agents such as lamivudine and dolutegravir. Generic pharmaceutical manufacturers source this material for finished dosage form production under regulatory filings including ANDAs and MAAs.
Specialty API distributors also supply it to formulators developing pediatric antiretroviral preparations. These oral liquid formats require high-purity, well-characterized material to ensure safety and efficacy.
The product is supplied as a white to off-white crystalline powder. It is available in pharmaceutical-grade specifications conforming to USP and BP monographs for global compliance.
GMP -certified material is required for regulated drug product manufacturing to meet international standards. Packaging is typically offered in controlled quantities suited to standard API handling protocols.
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Physical Properties
| Melting Point | 222-225°C |
| Appearance | White Solid |
| Color | white to tan |
| Form | powder |
| Water Solubility | 1.68ug/L(32 ºC) |
Safety & Handling
Danger GHS05 GHS07 GHS08 Hazard Statements H317 May cause an allergic skin reaction H318 Causes serious eye damage H341 Suspected of causing genetic defects H351 Suspected of causing cancer H361 Suspected of damaging fertility or the unborn child Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection. P317 Get emergency medical help. P318 IF exposed or concerned, get medical advice. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P333+P317 Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 2933595960 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 188062-50-2
- EC Number
- 620-488-4
- Mol. Weight
- 670.7
- HS Code
- 2933595960
- Category
- Heterocyclic Compounds