Overview
Chlorhexidine gluconate (CAS 18472-51-0 ), commonly abbreviated as CHG and also known as chlorhexidine digluconate, is a broad-spectrum antimicrobial agent used across pharmaceutical and personal care manufacturing.
It delivers sustained bactericidal and antifungal activity, making it a preferred active ingredient in antiseptic and preservative formulations. In healthcare settings, CHG is the active ingredient in surgical scrubs.
It is used in pre-operative skin preparation products and wound care formulations. Oral care products such as prescription-strength mouth rinses rely on CHG for its substantive binding to oral mucosa.
This provides prolonged antimicrobial action against plaque-forming bacteria. Personal care formulators incorporate it into hand sanitizers, intimate hygiene products, and medicated cleansers.
It is used where preservative efficacy and skin compatibility are both required. It also functions as a preservative in ophthalmic solutions and contact lens care products at low concentrations.
Chlorhexidine gluconate is supplied primarily as an aqueous solution, with 20% and 5% concentrations being the most common commercial forms. Pharmaceutical-grade material is available to USP standards.
The material is also available to BP and Ph. Eur. specifications. Bulk supply is standard for industrial and pharmaceutical buyers, with solution concentration being a key procurement parameter.
Grade specification remains a critical factor for buyers in the chemical industry. These standards ensure the material meets the rigorous safety requirements for medical and consumer applications.
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Physical Properties
| Density | 1.06 g/mL at 25 °C(lit.) |
| Appearance | Almost colourless or pale-yellowish liquid. |
| Color | Colorless |
| Form | Liquid |
| Water Solubility | 750g/L at 20℃ |
| Vapor Pressure | 0.005Pa at 25℃ |
| Log P | -1.81 at 20.7℃ |
Safety & Handling
Danger GHS05 GHS07 GHS09 GHS08 Hazard Statements H302 Harmful if swallowed H317 May cause an allergic skin reaction H318 Causes serious eye damage H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled H400 Very toxic to aquatic life H410 Very toxic to aquatic life with long lasting effects Precautionary Statements P233 Keep container tightly closed. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P284 In case of inadequate ventilation wear respiratory protection. P317 Get emergency medical help. P321 Specific treatment (see … on this label). P330 Rinse mouth. P391 Collect spillage. P403 Store in a well-ventilated place. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333+P317 Get emergency medical help. P342+P316 Get emergency medical help immediately. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29252900 |
| UN Number | 3082 |
| ADR Class | 9 |
| Packing Group | III |
| Storage Class | 12 - Non Combustible Liquids |
Other Names
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Chemical Properties
- CAS Number
- 18472-51-0
- EC Number
- 242-354-0
- Mol. Weight
- 897.8
- HS Code
- 29252900
- Category
- Pharmaceutical Intermediates