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Pharmaceutical Intermediates

Chlorphenesin

CAS: 104-29-0

Overview

Chlorphenesin (CAS 104-29-0 ), also known as p-chlorophenyl-alpha-glyceryl ether, is a synthetic antimicrobial active used across cosmetic and pharmaceutical formulations. It functions as a preservative and biocide, inhibiting microbial growth to extend product shelf life.

In personal care, this compound is used as a preservative in rinse-off and leave-on products including moisturizers, cleansers, and hair care formulations. It is often used in combination with other preservatives to broaden the antimicrobial spectrum.

Pharmaceutical manufacturers incorporate it into topical preparations where controlled microbial protection is required without the regulatory burden of more restricted preservative systems. Its compatibility with a range of cosmetic actives makes it a practical option.

Formulators developing paraben-free preservation systems frequently select this ingredient for its stability and efficacy. It is also evaluated as a pharmaceutical intermediate in select synthesis pathways targeting chlorinated glycerol ether derivatives.

The material is supplied as a white crystalline powder. Standard market grades include cosmetic/personal care grade and pharmaceutical-grade material, with suppliers typically offering documentation aligned to USP or in-house specifications.

Packaging is available in kilogram quantities for development use through to bulk supply for commercial manufacturing. This ensures that both small-scale laboratories and large industrial facilities can source the material according to their specific production needs.

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Physical Properties

Melting Point78 °C
Boiling Point290.96°C (rough estimate)
Density1.2411 (rough estimate)
ColorWhite to Off-White
FormSolid
Water SolubilitySlightly soluble in water.
Vapor Pressure0Pa at 25℃
Refractive Index1.5470 (estimate)
Log P1.23 at 23℃

Safety & Handling

Danger GHS05 GHS07 Hazard Statements H302 Harmful if swallowed H315 Causes skin irritation H318 Causes serious eye damage H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P317 Get emergency medical help. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29094990

Other Names

P-Chlorophenyl-alpha-glyceryl ether | Glycerol alpha-P-chlorophenyl ether | Chlorphénésine | 3-(P-Chlorophenoxy)propane-12-diol | 3-(P-Chlorophenoxy)-12-propanediol | 3-(4-Chlorophenoxy)-12-propanediol | 3-(4-chlorophenoxy)propane-12-diol | 12-Propanediol3-(4-chlorophenoxy)-

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Chemical Properties

CAS Number
104-29-0
EC Number
203-192-6
Mol. Weight
202.63
HS Code
29094990

Industries

Documentation