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Pharmaceutical Intermediates

Imidazole

CAS: 288-32-4

Overview

Imidazole (CAS 288-32-4 ) is a five-membered nitrogen-containing heterocycle used across pharmaceutical synthesis, polymer chemistry, and industrial processing. Its primary commercial value lies in its dual function as a synthetic building block and a buffering agent.

In pharmaceutical manufacturing, it serves as a key intermediate in the synthesis of antifungal agents, antihistamines, and a broad range of active pharmaceutical ingredients. It is essential for creating molecules containing the imidazole ring structure.

Epoxy resin formulators use it as a curing agent and cure accelerator, particularly in electronics-grade laminates and adhesive systems. This allows for controlled crosslinking and improved thermal stability in high-performance materials.

In water treatment and industrial processes, it functions as a pH buffer and corrosion inhibitor precursor. These applications rely on its chemical stability and ability to maintain specific environmental conditions during processing.

Agricultural chemical producers also incorporate it as an intermediate in the synthesis of imidazole-based fungicides and plant growth regulators. This versatility makes it a staple chemical for large-scale agrochemical manufacturing.

The product is supplied as a white crystalline solid or flake. Standard commercial grades include technical grade for industrial applications and high-purity grades meeting USP and Ph. Eur. specifications for pharmaceutical use.

Bulk quantities are available in fiber drums or bags, with reagent-grade material offered for laboratory and research procurement. We ensure consistent quality and supply chain reliability for all industrial and life science applications.

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Physical Properties

Melting Point90.5 °C
Boiling Point256.00 °C
Density1.12 g/cm³
Flash Point293 °F
AppearanceWhite to off white crystals
Colorwhite
OdorAmine like
Formcrystalline
Water Solubility633 g/L (20 ºC)
Vapor Pressure<1 mm Hg ( 20 °C)
Refractive Index1.4801
pH9.5-11.0 (25℃, 50mg/mL in H2O)
Log P-0.02 at 25℃

Safety & Handling

Danger GHS05 GHS07 GHS08 Hazard Statements H302 Harmful if swallowed H314 Causes severe skin burns and eye damage H318 Causes serious eye damage H319 Causes serious eye irritation H360 May damage fertility or the unborn child H361 Suspected of damaging fertility or the unborn child H371 May cause damage to organs Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P318 IF exposed or concerned, get medical advice. P321 Specific treatment (see … on this label). P330 Rinse mouth. P363 Wash contaminated clothing before reuse. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P308+P316 Get emergency medical help immediately. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29332900
UN Number2923
ADR Class8
Packing GroupIII
Storage Class6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
WGK (Germany)1

Other Names

pyrro[b]monazole | NN'-vinyleneformamidine | NN'-12-ethenediylmethanimidamide | miazole | iminazole | glyoxalin | 13-diaza-24-cyclopentadiene | IMD

Related Products

Chemical Properties

CAS Number
288-32-4
EC Number
206-019-2
Mol. Weight
68.08
HS Code
29332900

Industries

Documentation