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Pigments & Colorants

2-chloronicotinic acid

CAS: 2942-59-8

Overview

2-Chloronicotinic acid (CAS 2942-59-8 ) is a halogenated pyridinecarboxylic acid used primarily as a building block in pharmaceutical synthesis and agrochemical manufacturing.

Its reactive chloro and carboxylic acid groups make it a reliable intermediate for constructing more complex heterocyclic structures across multiple industries and chemical research applications.

In pharmaceutical development, it serves as a key intermediate in the synthesis of active pharmaceutical ingredients, particularly antiviral, antibacterial, and CNS-targeted compounds.

Agrochemical formulators use it to produce herbicide and fungicide active substances, where the chloropyridine scaffold contributes significantly to the final biological activity.

In specialty chemical manufacturing, it functions as a precursor for flame retardant additives and catalyst components used in various types of polymer processing and stabilization.

Personal care and textile applications draw on its reactivity for surface modification agents and preservation chemistry in formulated products requiring specific chemical stability.

This product is supplied as a white to off-white crystalline powder. Standard commercial offerings include technical grade and high-purity grades suitable for pharmaceutical intermediate use.

Purity levels are typically at 98% or above confirmed by HPLC. Packaging ranges from small quantities for R&D procurement to bulk quantities for industrial-scale synthesis.

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Physical Properties

Melting Point194.00 °C
Boiling Point316.8±22.0 °C(Predicted)
Density1.470±0.06 g/cm3(Predicted)
AppearanceWhite to cream powder
ColorWhite to cream
OdorPungent odor
FormPowder
Log P0.988

Safety & Handling

Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29333999
Storage Class11 - Combustible Solids
WGK (Germany)3

Other Names

2-Chloropyridine-3-carboxylic acid | 2-Chloro-3-pyridinecarboxylic acid | 3-Pyridinecarboxylic acid2-chloro- | Nicotinic acid2-chloro- | 3-Carboxy-2-chloropyridine | CNIS

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Chemical Properties

CAS Number
2942-59-8
EC Number
220-937-0
Mol. Weight
157.55
HS Code
29333999

Industries

Documentation