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Pharmaceutical Intermediates

2-nitrobenzoic acid

CAS: 552-16-9

Overview

2-Nitrobenzoic acid (CAS 552-16-9 ), also known as o-nitrobenzoic acid, is an aromatic nitro compound used as a key building block in the synthesis of pharmaceutical intermediates and specialty chemicals.

Its reactive carboxyl and nitro groups make it a practical starting material for multi-step organic synthesis across several industrial sectors. In pharmaceutical manufacturing, it serves as a precursor.

It is used in the production of anthranilic acid derivatives, dyes, and active pharmaceutical ingredients requiring ortho-substituted benzoic acid frameworks. Pigment and colorant producers use it as an intermediate.

This chemical is essential in synthesizing azo dyes and other chromophoric structures for textile and industrial coating applications. In personal care formulations, it contributes to preservation systems.

It is also utilized for pH buffering where aromatic acid chemistry is required. Specialty chemical manufacturers apply it in surface modification agents and wetting formulations where controlled acidity is needed.

The aromatic character of this compound influences substrate interaction significantly. 2-Nitrobenzoic acid is supplied as an off-white to pale yellow crystalline powder for various industrial uses.

Technical grade is the standard commercial offering, with pharmaceutical-grade material available for regulated synthesis applications. Bulk quantities are typically offered in fiber drums or multi-layer bags.

Smaller packaging is available for laboratory and pilot-scale procurement. This ensures flexibility for both large-scale manufacturing and specialized research and development projects within the industry.

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Physical Properties

Melting Point147.5 °C
Boiling Point295.67°C (rough estimate)
Density1,58 g/cm 3
Appearanceoff-white powder
ColorOff-white
FormFine Powder
Water Solubility6.8 g/L
Refractive Index1.6280 (estimate)

Safety & Handling

Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29163900
Storage Class11 - Combustible Solids
WGK (Germany)3

Other Names

o-nitrobenzoic acid | o-Carboxynitrobenzene | Benzoic acid2-nitro- | ortho-nitrobenzoic acid | AI3-08821 | Benzoic acido-nitro- | NITROBENZOIC ACID

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Chemical Properties

CAS Number
552-16-9
EC Number
209-004-9
Mol. Weight
167.12
HS Code
29163900

Industries

Documentation