2-chloro-5-methoxyaniline

CAS: 2401-24-3

Overview

2-Chloro-5-methoxyaniline (CAS 2401-24-3 ), also known commercially as 6-chloro-m-anisidine, is an aromatic amine intermediate used in the synthesis of active pharmaceutical ingredients and specialty agrochemicals.

Its dual functional groups, a reactive amine and a chloro substituent, make it a building block for constructing complex heterocyclic and azo-based target molecules for various industrial applications.

In pharmaceutical synthesis, it serves as a key starting material for manufacturing drug candidates, particularly in programs targeting kinase inhibitors and other small-molecule therapeutics where precise substitution patterns are required.

Agrochemical manufacturers use it in the production of herbicide and fungicide active ingredients, where the chloro and methoxy groups direct selective reactivity during coupling steps in the manufacturing process.

Dye and pigment producers incorporate it into azo dye synthesis, where the aniline nitrogen undergoes diazotization to generate stable colorant intermediates for textile and industrial coatings.

It also appears in polymer research as a co-monomer or initiator component in specialty polymerization systems. This versatile chemical is typically supplied as a liquid or low-melting solid for easy handling.

It is available in technical grade for industrial synthesis and in higher-purity grades suited to pharmaceutical intermediate applications. Packaging ranges from small research quantities to bulk drum supply.

Physical Properties

Melting Point	27 °C
Boiling Point	136-137 °C @ Press: 10 Torr
Density	1.261 g/mL at 25 °C
Flash Point	135-137°C/12mm
Color	White or Colorless to Yellow to Orange
Form	powder to lump to clear liquid
Water Solubility	Slightly soluble in water.
Refractive Index	1.5848

Safety & Handling

Danger GHS06 GHS07 GHS08 Hazard Statements H301 Toxic if swallowed H302 Harmful if swallowed H311 Toxic in contact with skin H312 Harmful in contact with skin H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation H373 May causes damage to organs through prolonged or repeated exposure Precautionary Statements P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P262 Do not get in eyes, on skin, or on clothing. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P316 Get emergency medical help immediately. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code	2922290090
Storage Class	13 - Non Combustible Solids
WGK (Germany)	3

Other Names

Industries

Pharmaceuticals & Healthcare