Overview
Guanidinoacetic acid (CAS 352-97-6 ), also known as GAA or guanidoacetic acid, is the direct biosynthetic precursor to creatine and is produced commercially for use across nutritional, pharmaceutical, and personal care applications.
Its role as a creatine precursor positions it as a functional ingredient where creatine supplementation or metabolic support is the end objective. In animal nutrition and feed manufacturing, GAA is incorporated into livestock and poultry feed.
It is used as a creatine precursor to support muscle energy metabolism and improve feed conversion efficiency. Pharmaceutical formulators use it as a reference compound and active intermediate in creatine-related drug and supplement development.
In sports nutrition and dietary supplement manufacturing, GAA is formulated into capsules, powders, and blended products targeting creatine biosynthesis support. Personal care formulators have evaluated it as a humectant and buffering agent.
It is used in skin-conditioning formulations where amino acid-derived ingredients are preferred. Guanidinoacetic acid is supplied as a white crystalline powder and is available in feed-grade and technical-grade specifications.
Pharmaceutical-grade material is produced to USP or equivalent standards for supplement and drug applications. Packaging typically ranges from kilogram quantities for R&D procurement to bulk metric ton supply.
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Physical Properties
| Melting Point | >300 °C |
| Boiling Point | 218.88°C (rough estimate) |
| Density | 1.4020 (rough estimate) |
| Appearance | WHITE TO SLIGHTLY BEIGE FINE CRYSTALLINE POWDER |
| Color | White to Off-White |
| Form | Solid |
| Water Solubility | 3.6g/L(15 ºC) |
| Refractive Index | 1.4900 (estimate) |
Safety & Handling
Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29252000 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 3 |
Other Names
Related Products
Chemical Properties
- CAS Number
- 352-97-6
- EC Number
- 206-529-5
- Mol. Weight
- 117.11
- HS Code
- 29252000
- Category
- Amino Acids & Peptides