Overview
Glucamine (CAS 488-43-7 ) is an amino sugar alcohol used across pharmaceutical, cosmetic, and nutritional applications as a pH buffer, chelating agent, and humectant. It is the free amine base form commonly encountered in API salt formation and topical formulation chemistry.
In pharmaceuticals, this compound is used to form salt complexes with acidic active ingredients, improving solubility and bioavailability in oral and injectable drug products. Cosmetic formulators incorporate it into moisturizing creams and serums where it buffers pH levels.
It simultaneously binds trace metal ions that would otherwise destabilize the formulation. In skin care, its humectant function supports water retention in the stratum corneum, making it relevant for leave-on products targeting dry or sensitive skin.
Food and nutritional supplement manufacturers use it as a processing aid and buffering component in mineral delivery systems. The material is supplied as a white to off-white crystalline powder for various industrial uses.
It is available in pharmaceutical-grade specifications aligned with research and API manufacturing requirements. This ensures the material meets the rigorous demands of the healthcare sector and specialized chemical synthesis.
The product is also offered as technical-grade material for industrial cosmetic production. Packaging typically ranges from kilogram-scale laboratory quantities to multi-kilogram bulk for commercial manufacturing needs.
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Physical Properties
| Melting Point | 127 °C |
| Boiling Point | 314.29°C (rough estimate) |
| Density | 1.3243 (rough estimate) |
| Flash Point | 230°C |
| Appearance | Crystalline Solid |
| Color | White to Pale Yellow |
| Form | Solid |
| Refractive Index | -7 ° (C=10, H2O) |
Safety & Handling
Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation Precautionary Statements P264 Wash … thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P321 Specific treatment (see … on this label). P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29400090 |
Other Names
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Chemical Properties
- CAS Number
- 488-43-7
- EC Number
- 207-677-3
- Mol. Weight
- 181.19
- HS Code
- 29400090
- Category
- Alcohols & Glycols