Titanium isopropoxide

CAS: 546-68-9

Overview

Titanium isopropoxide (CAS 546-68-9 ), commonly abbreviated as TTIP and also known as tetraisopropyl orthotitanate, is a reactive organotitanium compound used as a catalyst precursor.

It functions as a sol-gel processing agent across specialty chemical manufacturing. It enables controlled deposition of titanium dioxide coatings and serves as a crosslinking agent in polymer systems.

In sol-gel and thin-film processes, TTIP is hydrolyzed to deposit TiO₂ layers on glass, metal, and plastic substrates for photocatalytic, anti-reflective, or barrier coating applications.

Polymer manufacturers use it as a crosslinker for polyesters and alkyd resins, improving adhesion and film integrity in coatings and adhesives for industrial use.

In personal care and cosmetic formulations, it functions as a surface-modification agent for treating pigment particles, particularly titanium dioxide used in sunscreens and color cosmetics.

Pharmaceutical and biotech applications include its use as a catalyst in stereoselective synthesis, notably in asymmetric epoxidation reactions for high-purity chemical production.

TTIP is supplied as a moisture-sensitive liquid, typically at 97% or higher purity. Technical and reagent grades are the most commonly available for industrial procurement.

Packaging ranges from small laboratory quantities to bulk drums under inert atmosphere. Handling and storage requirements under dry, inert conditions are standard for this material.

Physical Properties

Melting Point	~20 °C (approx)
Boiling Point	220 °C @ Press: 760 Torr
Density	0.9711 g/cm³ @ Temp: 20 °C
Flash Point	72 °F
Appearance	colourless to light yellow liquid
Color	Colorless to pale yellow
Form	Liquid
Water Solubility	HYDROLYSIS
Vapor Pressure	60.2hPa at 25℃
Refractive Index	n 20/D 1.464(lit.)
Log P	0.05

Safety & Handling

Danger GHS02 GHS05 GHS07 Hazard Statements H226 Flammable liquid and vapor H318 Causes serious eye damage H319 Causes serious eye irritation H332 Harmful if inhaled H336 May cause drowsiness or dizziness Precautionary Statements P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P317 Get emergency medical help. P319 Get medical advice/attention if you feel unwell. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P370+P378 Use … for extinction. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P403+P235 Store in a well-ventilated place. Keep cool. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code	29051900
UN Number	2413
ADR Class	3
Packing Group	III
Storage Class	3 - Flammable liquids
WGK (Germany)	2

Other Names

Industries

Biotechnology & Life Sciences Personal Care & Cosmetics Plastics & Polymers Pharmaceuticals & Healthcare