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Amino Acids & Peptides

Choline chloride

CAS: 67-48-1

Overview

Choline chloride (CAS 67-48-1 ), also sold under the names Lipotril and Paresan, is a quaternary ammonium salt classified as a B-complex vitamin essential to animal metabolism. Approved as food additive E1001(iii) , it functions as a nutrient supplement, humectant, and processing aid across feed, food, and pharmaceutical manufacturing.

In animal feed production, it is the primary source of dietary choline for poultry, swine, and aquaculture, where deficiency directly impacts liver function and growth performance. Food and beverage manufacturers use it as a nutrient fortifier in functional foods, infant formula, and dietary supplements.

These supplements often target cognitive and metabolic health. In pharmaceutical formulations, it serves as an active ingredient in lipotropic preparations and as a buffering agent in liquid dosage forms. Personal care formulators incorporate it into moisturizing products where its hygroscopic character supports water retention.

Choline chloride is supplied as a dry corn cob or silica carrier-based powder, typically containing fifty to seventy percent active content, for feed applications. It is also available as an aqueous solution, commonly seventy to seventy-five percent, for liquid feed and industrial use.

Anhydrous crystalline grades are available for pharmaceutical and food applications meeting USP and FCC specifications. These high-purity grades ensure compliance with international safety standards for human consumption and medical use.

The material is highly hygroscopic and must be stored in a cool, dry environment to prevent clumping. Proper handling ensures the stability of the compound across various industrial applications, from large-scale agriculture to specialized laboratory settings.

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Physical Properties

Melting Point305 °C (decomp)
Density1.254 x 10⁻³ g/cm³ @ Temp: 25 °C; Press: 750 Torr
AppearanceWhite crystalline powder
ColorWhite
Odorsl. odor of trimethylamine
FormAdhering Crystals
Water Solubilitysoluble
Refractive Index1.5400 (estimate)
pH5.0-7.5 (25℃, 1M in H2O)
Log P-3.70

Safety & Handling

Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29231000
Storage Class11 - Combustible Solids
WGK (Germany)1

Other Names

Lipotril | 2-Hydroxy-NNN-trimethylethanaminium chloride | Paresan | (2-Hydroxyethyl)trimethylammonium chloride | Biocolina | Biocoline | Ethanaminium2-hydroxy-NNN-trimethyl-chloride (1:1) | Ethanaminium2-hydroxy-NNN-trimethyl-chloride | E1001(iii)

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Chemical Properties

CAS Number
67-48-1
EC Number
200-655-4
Mol. Weight
139.62
HS Code
29231000

Industries

Documentation