Overview
Lithium amide (CAS 7782-89-0 ), also known as Lithamide, is a strong inorganic base used as a reagent and catalyst in synthetic chemistry. It functions as a deprotonating agent and polymerization initiator across pharmaceutical, polymer, and biotechnology manufacturing processes.
In pharmaceutical synthesis, lithium amide drives condensation and deprotonation reactions to produce active pharmaceutical intermediates where precise base strength is critical. Polymer manufacturers use it to initiate anionic polymerization of monomers.
This includes monomers such as styrene and butadiene, controlling molecular weight distribution in specialty elastomers and resins. In biotechnology research and production, it supports the synthesis of complex organic molecules requiring selective nitrogen-based base chemistry.
It also serves as a pH-regulating catalyst in specialty chemical processes where conventional bases would introduce unwanted counterions or side reactions. Lithium amide is supplied as a white crystalline powder, typically handled and packaged under inert atmosphere.
Due to its reactivity with moisture, it is available in technical and high-purity grades to meet the differing demands of industrial polymer production and pharmaceutical intermediate synthesis. Packaging formats range from small quantities for laboratory use to bulk quantities.
These formats support both R&D use and commercial manufacturing requirements. The material is manufactured to meet rigorous industrial specifications, ensuring consistent performance across diverse chemical applications and large-scale production environments.
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Physical Properties
| Melting Point | 380-400 °C |
| Boiling Point | 430 °C |
| Density | 1.178 g/cm³ @ Temp: 17.5 °C |
| Appearance | white to grey fine powder |
| Color | off-white |
| Form | powder |
| Water Solubility | reacts |
| Refractive Index | 1.178g/mL |
| Log P | 0.23 at 25℃ |
Safety & Handling
Danger GHS02 GHS05 Hazard Statements H251 Self-heating; may catch fire H261 In contact with water releases flammable gas H314 Causes severe skin burns and eye damage H318 Causes serious eye damage H412 Harmful to aquatic life with long lasting effects Precautionary Statements P235 Keep cool. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P321 Specific treatment (see … on this label). P363 Wash contaminated clothing before reuse. P405 Store locked up. P407 Maintain air gap between stacks/pallets. P410 Protect from sunlight. P413 Store bulk masses greater than … kg/… lbs at temperatures not exceeding … °C/…°F. P420 Store away from other materials. P501 Dispose of contents/container in accordance with local regulations. P231+P232 Handle and store contents under inert gas/… . P264+P265 Wash … thoroughly after handling. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P370+P378 Use … for extinction. P402+P404 Store in a dry place. Store in a closed container. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 28530090 |
| UN Number | 1390 |
| ADR Class | 4.3 |
| Packing Group | II |
| Storage Class | 4.3 - Hazardous materials which set free flammable gases upon contact with water |
| WGK (Germany) | 2 |
Other Names
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Chemical Properties
- CAS Number
- 7782-89-0
- EC Number
- 231-968-4
- Mol. Weight
- 23.0
- HS Code
- 28530090
- Category
- Organometallic Compounds