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Amines

Acetamide

CAS: 60-35-5

Overview

Acetamide (CAS 60-35-5 ), also known as acetic acid amide, is the simplest aliphatic amide and functions as a solvent, plasticizer, and chemical intermediate across pharmaceutical, cosmetic, and biotechnology manufacturing.

With FEMA number 4251 , it is recognized in flavoring applications and serves as a building block for synthesis of more complex amide-based compounds in various industrial processes.

In pharmaceutical manufacturing, acetamide acts as a reaction intermediate and catalyst precursor in the synthesis of active pharmaceutical ingredients requiring specific amide bond formation during the production cycle.

Personal care formulators use it as a humectant and surface-modifying agent in skin conditioning products, where it supports moisture retention at the formulation level for high-quality cosmetic goods.

Biotechnology applications include its use as a buffering component and nitrogen source in microbial culture media and biochemical assay systems used for research and development purposes.

In specialty chemical synthesis, it functions as a catalyst precursor and pH-regulating agent in controlled reaction environments to ensure consistent results across different manufacturing batches.

Acetamide is supplied as a white crystalline solid or powder. Standard commercial grades include technical and pharmaceutical-grade material, with purity levels typically ranging from 98% to 99%+.

Packaging is available in laboratory quantities through to bulk industrial supply to meet both R&D and production-scale procurement requirements for global chemical distribution networks.

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Physical Properties

Melting Point81 °C
Boiling Point222 °C @ Press: 760 Torr
Density1.159 g/cm³ @ Temp: 20 °C
Flash Point220-222°C
AppearanceAcetamide is a colorless to yellow, deliquescent, crystalline solid. Odorless if pure, “mousy” odor if impure. Odor threshold5140 160 milligram per cubic meter.
ColorWhite
OdorMousy odor
FormCrystals
Water Solubility2000 g/L (20 ºC)
Vapor Pressure1 mm Hg ( 65 °C)
Refractive Index1.4274
Log P-1.26

Safety & Handling

Warning GHS08 Hazard Statements H316 Causes mild skin irritation H320 Causes eye irritation H351 Suspected of causing cancer H361 Suspected of damaging fertility or the unborn child Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P280 Wear protective gloves/protective clothing/eye protection/face protection. P318 IF exposed or concerned, get medical advice. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29241900
UN Number3077
ADR Class9
Packing GroupIII
Storage Class11 - Combustible Solids
WGK (Germany)1

Other Names

Acetic acid amide | Acetimidic acid | Ethanimidic acid | Amid kyseliny octove | NCI-C02108 | CH3CONH2

Related Products

Chemical Properties

CAS Number
60-35-5
EC Number
200-473-5
Mol. Weight
59.07
HS Code
29241900
Category
Amines

Industries

Documentation