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Pharmaceutical Intermediates

Pantolactone

CAS: 79-50-5

Overview

Pantolactone (CAS 79-50-5 ), also supplied as DL-Pantolactone, is a cyclic lactone intermediate used across pharmaceutical synthesis, cosmetic formulation, and food processing. It functions primarily as a chiral building block and stabilizing agent.

This chemical is essential in the production of pantothenic acid (Vitamin B5) and related compounds. In pharmaceutical manufacturing, it serves as a key precursor in the synthesis of pantothenic acid and coenzyme A derivatives.

Controlled stereochemistry drives sourcing decisions for this material in medical applications. Cosmetic formulators incorporate it into skin care products for its moisture-retention properties, supporting hydration in serums and creams.

It is also utilized in hair conditioning treatments to improve texture and health. In food and flavor applications, it contributes stabilizing functionality to nutrient premixes and various fortified products.

Research and fine chemical producers source it as a resolved or racemic chiral synthon for asymmetric synthesis programs. The material is available as a white crystalline powder or solid for industrial use.

It is supplied in both racemic (DL) and optically active forms to meet specific needs. Purity grades range from technical to high-purity pharmaceutical-grade material, often meeting USP or FCC standards.

Packaging typically ranges from kilogram quantities to bulk drums, depending on application requirements. This versatility ensures that both laboratory and large-scale manufacturing needs are met efficiently.

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Physical Properties

Melting Point48-49 °C
Boiling Point64 °C @ Press: 0.15 Torr
Density1.165±0.06 g/cm3(Predicted)
Flash Point122°C
ColorColourless Gel to White to Off-White
FormSolid
Water SolubilityH2O: 1g/10 mL, clear, colorless to almost colorless

Safety & Handling

Warning GHS07 Hazard Statements H319 Causes serious eye irritation Precautionary Statements P280 Wear protective gloves/protective clothing/eye protection/face protection. P264+P265 Wash … thoroughly after handling. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29322090
WGK (Germany)3

Other Names

RefChem:390767 | DL-Pantolactone | 3-hydroxy-44-dimethyldihydrofuran-2(3H)-one | 3-hydroxy-44-dimethyloxolan-2-one | DL-Pantoyl Lactone | 2(3H)-Furanonedihydro-3-hydroxy-44-dimethyl- | Butyric acidαγ-dihydroxy-ββ-dimethyl-γ-lactone | Dihydro-3-hydroxy-44-dimethyl-2(3H)-furanone

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Chemical Properties

CAS Number
79-50-5
EC Number
201-210-7
Mol. Weight
130.14
HS Code
29322090

Industries

Documentation