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Pharmaceutical Intermediates

Calcium salicylate

CAS: 824-35-1

Overview

Calcium salicylate ( CAS 824-35-1 ), also known as calcium disalicylate, is the calcium salt of salicylic acid used across pharmaceutical and personal care manufacturing. It functions as a preservative and pH-buffering agent.

This chemical is often selected for formulations where sodium or free-acid forms are unsuitable due to solubility or compatibility constraints. In pharmaceutical manufacturing, it serves as an intermediate in the synthesis of salicylate-based active ingredients.

It also acts as a buffering component in tablet and oral formulation development. Personal care formulators incorporate it into topical preparations where controlled preservation and mild acidity management are required.

The compound provides these benefits without the irritation profile of free salicylic acid. It is also evaluated in dermatological formulations targeting exfoliation and skin conditioning for various consumer products.

The calcium salt form offers a more neutral delivery vehicle for sensitive applications. Compounding pharmacies and specialty chemical manufacturers source it as a starting material for further salt conversions.

It is also utilized for custom API development in specialized medical fields. Calcium salicylate is supplied as a white crystalline powder available in pharmaceutical-grade specifications aligned with compendial standards.

These standards include USP , BP , and EP relevant to medicinal and cosmetic applications. Packaging options typically range from laboratory-scale quantities to bulk industrial supply depending on requirements.

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Physical Properties

Formsolid
Log P2.061 (est)

Safety & Handling

Warning GHS07 Hazard Statements H302 Harmful if swallowed [Warning Acute toxicity, oral]

Trade & Regulatory

Storage Class11 - Combustible Solids
WGK (Germany)3

Other Names

Calcium disalicylate | Benzoic acid2-hydroxy-calcium salt (2:1) | 0841QCS0DK | RefChem:573557 | Salicylic acidcalcium salt (2:1) | Cyl-Re | Helioscin

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Chemical Properties

CAS Number
824-35-1
EC Number
212-525-4
Mol. Weight
314.30

Industries

Documentation