Overview
5-Chlorosalicylic acid (CAS 321-14-2 ), also referenced in procurement as 5-CSA, is an organochlorine derivative of salicylic acid used as a building block in pharmaceutical synthesis and as a functional additive in industrial formulations.
Its combination of phenolic and carboxylic acid groups makes it a reactive intermediate for producing active pharmaceutical ingredients and specialty performance chemicals. In pharmaceutical manufacturing, 5-CSA serves as a key intermediate.
It is used in the synthesis of antimicrobial and anti-inflammatory APIs, where controlled chlorination and hydroxyl positioning are critical to the final molecule's activity. Coating and resin formulators incorporate it as a UV stabilizer.
It also acts as an antioxidant to extend the service life of protective coatings exposed to outdoor weathering. In adhesive and sealant systems, it contributes biocidal and preservation properties that inhibit microbial degradation.
These properties help maintain the product's shelf life. Personal care formulators also evaluate it as a preservative-boosting component in leave-on and rinse-off products where broad-spectrum efficacy is required.
5-Chlorosalicylic acid is supplied as a white to off-white crystalline powder. Technical and pharmaceutical-grade material is available, with pharmaceutical-grade product typically meeting defined purity thresholds.
This grade is suitable for API intermediate use. Packaging ranges from kilogram-scale laboratory quantities to bulk drum supply for industrial procurement, ensuring flexibility for various manufacturing scales and requirements.
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Physical Properties
| Melting Point | 171.5 °C |
| Boiling Point | 244.67°C (rough estimate) |
| Density | 1.3766 (rough estimate) |
| Appearance | OFF-WHITE TO CREAM POWDER |
| Color | White to Almost white |
| Form | powder to crystal |
| Water Solubility | 1 g/L (20 ºC) |
| Refractive Index | 1.4580 (estimate) |
| pH | 2.5 (H2O, 20℃)(aqueous suspension) |
| Log P | 3.090 |
Safety & Handling
Danger GHS06 GHS07 Hazard Statements H301 Toxic if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P316 Get emergency medical help immediately. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29182990 |
| UN Number | 2811 |
| ADR Class | 6.1 |
| Packing Group | III |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 321-14-2
- EC Number
- 206-283-9
- Mol. Weight
- 172.56
- HS Code
- 29182990
- Category
- Pharmaceutical Intermediates