Overview
Acetylsalicylic acid (CAS 50-78-2 ) is a synthetic salicylate derivative used across pharmaceutical manufacturing, personal care formulation, and specialty chemical applications. It functions primarily as an active pharmaceutical ingredient and chemical intermediate.
In pharmaceutical manufacturing, ASA is the active ingredient in analgesic, antipyretic, and antiplatelet solid dosage forms. These include tablets, effervescent formulations, and coated pellets for various medical applications.
Personal care formulators incorporate it as a keratolytic and preservation-supporting agent in exfoliating creams and scalp treatments. It is also frequently utilized in the production of anti-dandruff products and skin care solutions.
As a chemical intermediate, it serves in the synthesis of salicylate-based compounds where controlled acetylation is required. This versatility makes it a staple in industrial chemical synthesis and laboratory research.
In food-contact and specialty applications, its antioxidant and mild acidulant properties support stabilization in defined regulatory frameworks. It plays secondary roles in preservation and pH-related formulation work across industries.
Acetylsalicylic acid is supplied as a white crystalline powder in pharmaceutical and technical grades. USP , BP , and Ph.Eur. specifications are standard for pharmaceutical procurement and quality assurance.
Particle size distribution is often specified for tableting or coating processes to ensure manufacturing efficiency. Bulk quantities are available for industrial buyers requiring consistent material for large-scale production runs.
Pharma-grade material typically requires full documentation including CoA and residual solvent profiles. This ensures compliance with global safety standards and rigorous quality control protocols for sensitive applications.
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Physical Properties
| Melting Point | 135 °C |
| Boiling Point | 140 °C |
| Density | 1.40 g/cm³ |
| Flash Point | 250 °C |
| Appearance | Acetylsalicylic acid is a white crystalline solid with a slightly bitter taste. It is odorless but hydrolyzes in moist air to give an acetic acid odor |
| Color | white |
| Form | crystalline |
| Water Solubility | 3.3 g/L (20 ºC) |
| Refractive Index | 1.4500 (estimate) |
| Log P | 1.190 |
Safety & Handling
Warning GHS07 GHS08 Hazard Statements H302 Harmful if swallowed H315 Causes skin irritation H316 Causes mild skin irritation H319 Causes serious eye irritation H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled H335 May cause respiratory irritation H360 May damage fertility or the unborn child H370 Causes damage to organs H371 May cause damage to organs H372 Causes damage to organs through prolonged or repeated exposure H373 May causes damage to organs through prolonged or repeated exposure H412 Harmful to aquatic life with long lasting effects Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P233 Keep container tightly closed. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P284 In case of inadequate ventilation wear respiratory protection. P318 IF exposed or concerned, get medical advice. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P403 Store in a well-ventilated place. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P308+P316 Get emergency medical help immediately. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P342+P316 Get emergency medical help immediately. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29182200 |
| UN Number | 1851 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 1 |
Other Names
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Chemical Properties
- CAS Number
- 50-78-2
- EC Number
- 200-064-1
- Mol. Weight
- 180.16
- HS Code
- 29182200
- Category
- Flavors & Fragrances