Overview
Phylloquinone (CAS 84-80-0 ), commercially recognized as Vitamin K1, is the naturally occurring form of vitamin K derived primarily from plant sources. It functions as a bioactive nutrient in food fortification and pharmaceutical formulations.
This compound is also utilized in cosmetic preparations where coagulation-related and skin-conditioning activity is required. In pharmaceutical manufacturing, it is formulated into injectable solutions, oral capsules, and tablets.
These products target vitamin K deficiency and anticoagulant reversal protocols. Food and infant formula producers use it to fortify products to meet regulatory nutrient reference values across major global markets.
In cosmetic formulations, it is incorporated into eye creams, serums, and post-procedure skincare products. These applications target the appearance of dark circles and bruising through topical delivery systems.
Clinical nutrition manufacturers also include it in parenteral and enteral nutrition products requiring complete micronutrient profiles. It is supplied as a viscous oil in its pure form for various industrial uses.
Emulsified and water-dispersible formats are available for aqueous formulation systems. Standard grades include USP , BP , and Ph. Eur. , supporting pharmaceutical and clinical nutrition applications.
Food-grade material meeting FCC specifications is available for dietary supplement and fortified food production. This ensures compliance with international safety and quality standards for human consumption.
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Physical Properties
| Melting Point | -20 °C |
| Boiling Point | 140-145 °C @ Press: 1 x 10-3 Torr |
| Density | 0.964 g/cm³ @ Temp: 25 °C |
| Flash Point | >230 °F |
| Appearance | Phylloquinone is an odorless yellow viscous oil or crystals. |
| Color | Yellow to Dark Yellow |
| Odor | odorless |
| Form | viscous liquid |
| Water Solubility | Miscible with dehydrated alcohol, acetone, petroleum ether, hexane, dioxane, chloroform, ether, benzene and vegetable oils. Immiscible with water. |
| Refractive Index | n 20/D 1.527(lit.) |
| Log P | 10.305 (est) |
Safety & Handling
Warning GHS07 Hazard Statements H317 May cause an allergic skin reaction H413 May cause long lasting harmful effects to aquatic life Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P321 Specific treatment (see … on this label). P501 Dispose of contents/container in accordance with local regulations. P302+P352 IF ON SKIN: Wash with plenty of water. P333+P317 Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse.
Trade & Regulatory
| HS Code | 29369000 |
| UN Number | 1170 |
| Packing Group | II |
| Storage Class | 10 - Combustible liquids |
| WGK (Germany) | 2 |
Other Names
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Chemical Properties
- CAS Number
- 84-80-0
- EC Number
- 201-564-2
- Mol. Weight
- 450.7
- HS Code
- 29369000
- Category
- Vitamins & Nutrients