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Pharmaceutical Intermediates

4-Phenylphenol

CAS: 92-69-3

Overview

4-Phenylphenol (CAS 92-69-3 ), also known as 4-hydroxybiphenyl, is a hydroxylated biphenyl compound used as a biocide and preservative across personal care, pharmaceutical, and food-contact applications.

It functions as an antimicrobial agent and antioxidant stabilizer in formulations requiring broad-spectrum protection against microbial degradation. In personal care and cosmetics, it is incorporated into preservative systems.

This compound is used for creams, lotions, and rinse-off products where microbial contamination control is critical. Pharmaceutical manufacturers use it as an intermediate in the synthesis of active ingredients.

It also serves as a stabilizer in formulations sensitive to oxidative degradation. In food packaging and food-contact materials, it serves as a preservative additive where regulatory compliance governs sourcing.

Industrial disinfectant and surface treatment formulations also rely on it for its biocidal efficacy against bacteria and fungi. 4-Phenylphenol is supplied as a white to off-white crystalline powder or flakes.

Technical and pharmaceutical-grade material is available, with pharmaceutical intermediates typically meeting defined purity thresholds relevant to GMP manufacturing environments. Bulk quantities are standard for industrial scale.

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Physical Properties

Melting Point164-165 °C
Boiling Point305-308 °C
Density127 g/cm³ @ Temp: 25 °C
Flash Point330 °F
Appearancelight tan solid (odour threshold detection limit 0.7 ppm)
ColorWhite to slightly yellow
FormFlakes
Water Solubility0.7 g/L (20 ºC)
Vapor Pressure0Pa at 25℃
Refractive Index1.6188 (estimate)
pH7 (0.7g/l, H2O, 20℃)
Log P3.6 at 25℃

Safety & Handling

Warning GHS07 GHS09 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation H411 Toxic to aquatic life with long lasting effects Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29071900
UN Number3077
Storage Class13 - Non Combustible Solids
WGK (Germany)2

Other Names

[11'-Biphenyl]-4-ol | 4-HYDROXYBIPHENYL | Biphenyl-4-ol | p-Phenylphenol | 4-Biphenylol | p-Hydroxybiphenyl | p-Hydroxydiphenyl | 4-Hydroxydiphenyl

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Chemical Properties

CAS Number
92-69-3
EC Number
202-179-2
Mol. Weight
170.21
HS Code
29071900

Industries

Documentation