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Pharmaceutical Intermediates

4-biphenylcarboxylic acid

CAS: 92-92-2

Overview

4-Biphenylcarboxylic acid (CAS 92-92-2 ), also known as 4-phenylbenzoic acid, is an aromatic carboxylic acid used as a building block and intermediate across pharmaceutical, polymer, and specialty chemical manufacturing.

Its rigid biphenyl backbone makes it a preferred structural unit where defined molecular geometry is required in synthesis. In pharmaceutical manufacturing, it serves as a key intermediate in the synthesis of active pharmaceutical ingredients.

It is particularly useful in the production of sartans and other biphenyl-containing drug compounds. Polymer chemists incorporate it into liquid crystal polymer formulations and high-performance polyesters where thermal stability is critical.

Chain rigidity is a critical processing requirement for these materials. In coatings and adhesive systems, it functions as a crosslinking agent and pH modifier, contributing to formulation stability and film integrity.

Specialty catalyst development also draws on this compound as a ligand precursor or co-catalyst component in organometallic reaction systems. 4-Biphenylcarboxylic acid is supplied as a white to off-white crystalline powder.

Standard commercial offerings include technical grade and pharmaceutical-grade material, with purity specifications typically ranging from 98% to 99%+ by HPLC. Packaging is available in laboratory quantities through to bulk industrial volumes.

These options support both R&D and commercial-scale procurement for global manufacturers. The material is handled according to strict quality protocols to ensure consistency across different production batches and applications.

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Physical Properties

Melting Point228 °C
Boiling Point295.53°C (rough estimate)
Density1.1184 (rough estimate)
Appearancewhite to light yellow crystal powder
ColorWhite to beige
FormCrystalline Powder
Water SolubilityInsoluble in water.
Refractive Index1.5954 (estimate)

Safety & Handling

Warning GHS07 Hazard Statements H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation Precautionary Statements P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P321 Specific treatment (see … on this label). P330 Rinse mouth. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29163900
Storage Class11 - Combustible Solids
WGK (Germany)1

Other Names

4-Carboxylbiphenyl | [11'-Biphenyl]-4-carboxylic acid | 4-Phenylbenzoic acid | 4-Carboxybiphenyl | p-Phenylbenzoic acid | Para phenyl benzoic acid | 4-Diphenylcarboxylic acid | 36J7VPO67K

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Chemical Properties

CAS Number
92-92-2
EC Number
202-203-1
Mol. Weight
198.22
HS Code
29163900

Industries

Documentation