Overview
4-Biphenylcarboxylic acid (CAS 92-92-2 ), also known as 4-phenylbenzoic acid, is an aromatic carboxylic acid used as a building block and intermediate across pharmaceutical, polymer, and specialty chemical manufacturing.
Its rigid biphenyl backbone makes it a preferred structural unit where defined molecular geometry is required in synthesis. In pharmaceutical manufacturing, it serves as a key intermediate in the synthesis of active pharmaceutical ingredients.
It is particularly useful in the production of sartans and other biphenyl-containing drug compounds. Polymer chemists incorporate it into liquid crystal polymer formulations and high-performance polyesters where thermal stability is critical.
Chain rigidity is a critical processing requirement for these materials. In coatings and adhesive systems, it functions as a crosslinking agent and pH modifier, contributing to formulation stability and film integrity.
Specialty catalyst development also draws on this compound as a ligand precursor or co-catalyst component in organometallic reaction systems. 4-Biphenylcarboxylic acid is supplied as a white to off-white crystalline powder.
Standard commercial offerings include technical grade and pharmaceutical-grade material, with purity specifications typically ranging from 98% to 99%+ by HPLC. Packaging is available in laboratory quantities through to bulk industrial volumes.
These options support both R&D and commercial-scale procurement for global manufacturers. The material is handled according to strict quality protocols to ensure consistency across different production batches and applications.
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Physical Properties
| Melting Point | 228 °C |
| Boiling Point | 295.53°C (rough estimate) |
| Density | 1.1184 (rough estimate) |
| Appearance | white to light yellow crystal powder |
| Color | White to beige |
| Form | Crystalline Powder |
| Water Solubility | Insoluble in water. |
| Refractive Index | 1.5954 (estimate) |
Safety & Handling
Warning GHS07 Hazard Statements H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation Precautionary Statements P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P321 Specific treatment (see … on this label). P330 Rinse mouth. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29163900 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 1 |
Other Names
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Chemical Properties
- CAS Number
- 92-92-2
- EC Number
- 202-203-1
- Mol. Weight
- 198.22
- HS Code
- 29163900
- Category
- Pharmaceutical Intermediates