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Pharmaceutical Intermediates

Citicoline

CAS: 987-78-0

Overview

Citicoline (CAS 987-78-0 ), also known as CDP-choline, is a naturally occurring nucleotide compound used as an active ingredient in pharmaceutical formulations and functional health products. It supplies both choline and cytidine precursors in a single molecule.

This unique structure makes it a preferred raw material where combined bioavailability is a formulation requirement. In pharmaceutical manufacturing, it is the active substance in oral and injectable preparations targeting cognitive and neurological support.

Nutraceutical and dietary supplement producers incorporate it into capsules, sachets, and functional beverages. This is particularly common where choline-source labeling and documented bioavailability are key purchasing criteria for the end consumer.

Cosmetic formulators use it in premium skincare products as a humectant and membrane-supporting active. It is frequently found in anti-aging and barrier-repair formulations due to its specific biochemical properties and skin compatibility.

Biotechnology and life science suppliers also source it as a reference standard or biochemical reagent. It is widely used for cell culture and metabolic research applications where high-purity chemical precursors are necessary for study.

The material is supplied as a white to off-white hygroscopic powder, typically as the sodium salt form. This specific form offers improved stability for solid dosage manufacturing and long-term storage in industrial environments.

Standard grades include USP , BP , and Ph.Eur. to meet pharmaceutical procurement requirements. Food-grade and nutraceutical-grade material is also available for supplement applications where regulatory compliance is a prerequisite.

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Physical Properties

Melting Point>185°C (dec.)
ColorWhite
FormSolid
Log P-7.070 (est)

Safety & Handling

Warning GHS07 Hazard Statements H315 H315 H319 H319 H335 H335 Precautionary Statements P261 P261 P264 P264 P271 P271 P280 P280 P319 P319 P321 P321 P405 P405 P501 P501 P264+P265 P264+P265 P302+P352 P302+P352 P304+P340 P304+P340 P332+P317 P332+P317 P337+P317 P337+P317 P362+P364 P362+P364 P403+P233 P403+P233 P305+P351+P338 P305+P351+P338

Other Names

cytidine 5'-diphosphocholine | CDP-choline (neutral charge) | 5'-O-[hydroxy({[2-(trimethylammonio)ethoxy]phosphinato}oxy)phosphoryl]cytidine | CDP-choline | cytidine diphosphate choline | Nicholin | CDP-colina | Cytidine 5′-diphosphate choline

Related Products

Chemical Properties

CAS Number
987-78-0
EC Number
213-580-7
Mol. Weight
488.32

Industries

Documentation