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Vitamins & Nutrients

L-citrulline

CAS: 372-75-8

Overview

L-Citrulline (CAS 372-75-8 ) is a non-essential amino acid naturally occurring in watermelon and produced endogenously in the urea cycle. In commercial applications, it functions as a precursor to L-arginine.

It supports nitric oxide pathway activity that underpins its use across sports nutrition, pharmaceutical, and personal care formulations. In sports nutrition, it is a primary active ingredient in pre-workout powders.

These capsules target exercise performance and muscle recovery. Pharmaceutical manufacturers use it as an active or supporting ingredient in formulations addressing urea cycle disorders and cardiovascular-related indications.

In functional food and beverage development, it is incorporated into fortified drinks and nutritional bars where amino acid enrichment is a label claim. Personal care formulators include it in topical products.

It is used for its moisture-retention contribution and its role in supporting skin barrier function. This product is supplied as a white crystalline powder for various industrial and commercial applications.

Food-grade and USP -grade specifications are the most commonly traded forms. Food-grade material meets FCC standards for use in ingestible products and dietary supplement manufacturing.

Bulk quantities are available for industrial formulation. Pharmaceutical-grade material is subject to tighter purity and testing requirements to ensure compliance with global regulatory standards for safety.

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Physical Properties

Melting Point235.5 °C
Boiling Point306.48°C (rough estimate)
Density1.384 g/cm³ (solid)
AppearanceWhite powder
ColorWhite
OdorOdorless
FormCrystals or Crystalline Powder
Water Solubility200 g/L (20 ºC)
Refractive Index26 ° (C=8, 6mol/L HCl)
Log P-3.190

Safety & Handling

Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation Precautionary Statements P264 Wash … thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P321 Specific treatment (see … on this label). P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29241900
Storage Class11 - Combustible Solids
WGK (Germany)3

Other Names

δ-ureidonorvaline | α-amino-δ-ureidovaleric acid | N5-carbamoylornithine | N5-Carbamoyl-L-ornithine | N5-(Aminocarbonyl)ornithine | N(delta)-Carbamylornithine | N(5)-(Aminocarbonyl)-L-ornithine | L-2-Amino-5-ureidovaleric acid

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Chemical Properties

CAS Number
372-75-8
EC Number
206-759-6
Mol. Weight
175.19
HS Code
29241900

Industries

Documentation