Overview
L-Citrulline (CAS 372-75-8 ) is a non-essential amino acid naturally occurring in watermelon and produced endogenously in the urea cycle. In commercial applications, it functions as a precursor to L-arginine.
It supports nitric oxide pathway activity that underpins its use across sports nutrition, pharmaceutical, and personal care formulations. In sports nutrition, it is a primary active ingredient in pre-workout powders.
These capsules target exercise performance and muscle recovery. Pharmaceutical manufacturers use it as an active or supporting ingredient in formulations addressing urea cycle disorders and cardiovascular-related indications.
In functional food and beverage development, it is incorporated into fortified drinks and nutritional bars where amino acid enrichment is a label claim. Personal care formulators include it in topical products.
It is used for its moisture-retention contribution and its role in supporting skin barrier function. This product is supplied as a white crystalline powder for various industrial and commercial applications.
Food-grade and USP -grade specifications are the most commonly traded forms. Food-grade material meets FCC standards for use in ingestible products and dietary supplement manufacturing.
Bulk quantities are available for industrial formulation. Pharmaceutical-grade material is subject to tighter purity and testing requirements to ensure compliance with global regulatory standards for safety.
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Physical Properties
| Melting Point | 235.5 °C |
| Boiling Point | 306.48°C (rough estimate) |
| Density | 1.384 g/cm³ (solid) |
| Appearance | White powder |
| Color | White |
| Odor | Odorless |
| Form | Crystals or Crystalline Powder |
| Water Solubility | 200 g/L (20 ºC) |
| Refractive Index | 26 ° (C=8, 6mol/L HCl) |
| Log P | -3.190 |
Safety & Handling
Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation Precautionary Statements P264 Wash … thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P321 Specific treatment (see … on this label). P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29241900 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 372-75-8
- EC Number
- 206-759-6
- Mol. Weight
- 175.19
- HS Code
- 29241900
- Category
- Vitamins & Nutrients