Overview
Piperazine (CAS 110-85-0 ), also known commercially as Vermizine, is a cyclic diamine used as a reactive building block and process chemical across pharmaceutical manufacturing and polymer production.
Its bifunctional amine structure makes it a reliable intermediate for synthesizing active pharmaceutical ingredients and specialty materials. In pharmaceutical manufacturing, it serves as a key structural unit.
This chemical is used in the synthesis of numerous drug compounds, including antipsychotics, antihistamines, and antiparasitic agents. Polymer chemists use it as a curing agent and cross-linker in epoxy resin systems.
Controlled amine reactivity determines final mechanical performance in these systems. It also functions as a monomer in the production of polyamide membranes used in water treatment and industrial filtration.
In agrochemical synthesis, piperazine derivatives are incorporated into fungicide and pesticide formulations as core intermediates. This versatility makes it a staple in modern chemical manufacturing processes.
The product is supplied as white crystalline flakes or anhydrous powder, with piperazine hexahydrate available as an alternative hydrated form. Standard commercial grades include pharmaceutical-grade material.
The material meets USP and BP specifications, as well as technical-grade product for industrial polymer and chemical synthesis applications. Bulk quantities are typically offered in multi-kilogram bags.
These drums are suited to industrial procurement volumes and large-scale manufacturing needs. The material is handled according to strict safety protocols to ensure consistent quality and performance in all applications.
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Physical Properties
| Melting Point | 106 °C |
| Boiling Point | 146 °C @ Press: 760 Torr |
| Density | 1.1 g/cm³ |
| Flash Point | 65 °C |
| Appearance | Solid |
| Color | White to slightly yellow |
| Odor | at 0.10 % in dipropylene glycol. ammoniacal |
| Form | Crystalline Flakes |
| Water Solubility | 150 g/L (20 ºC) |
| Vapor Pressure | 0.8 mm Hg ( 20 °C) |
| Refractive Index | 1.4460 |
| pH | 11.0-12.5 (25℃, 0.1M in H2O) |
| Log P | -1.24 at 20-25℃ |
Safety & Handling
Danger GHS05 GHS08 GHS02 GHS07 Hazard Statements H228 Flammable solid H302 Harmful if swallowed H312 Harmful in contact with skin H314 Causes severe skin burns and eye damage H317 May cause an allergic skin reaction H318 Causes serious eye damage H332 Harmful if inhaled H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled H335 May cause respiratory irritation H361 Suspected of damaging fertility or the unborn child H370 Causes damage to organs H371 May cause damage to organs H372 Causes damage to organs through prolonged or repeated exposure H373 May causes damage to organs through prolonged or repeated exposure H402 Harmful to aquatic life Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P284 In case of inadequate ventilation wear respiratory protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P318 IF exposed or concerned, get medical advice. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P363 Wash contaminated clothing before reuse. P403 Store in a well-ventilated place. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P308+P316 Get emergency medical help immediately. P333+P317 Get emergency medical help. P342+P316 Get emergency medical help immediately. P362+P364 Take off contaminated clothing and wash it before reuse. P370+P378 Use … for extinction. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29335900 |
| UN Number | 2579 |
| ADR Class | 8 |
| Packing Group | III |
| Storage Class | 4.1B - Flammable solid hazardous materials |
| WGK (Germany) | 1 |
Other Names
Related Products
Chemical Properties
- CAS Number
- 110-85-0
- EC Number
- 203-808-3
- Mol. Weight
- 86.14
- HS Code
- 29335900
- Category
- Amines