Pyridine

CAS: 110-86-1

Overview

Pyridine ( CAS 110-86-1 ), also known by the abbreviation Py, is a foundational heterocyclic base used across pharmaceutical synthesis, agrochemical manufacturing, and specialty chemical production.

With FEMA 2966 status, it also holds a recognized role as a flavoring agent in food applications. In industrial settings, it functions primarily as a solvent, catalyst, and chemical intermediate.

In pharmaceutical manufacturing, pyridine serves as a reaction solvent and base catalyst in the synthesis of antihistamines, sulfonamides, and vitamins, where its ability to neutralize acids drives reaction efficiency.

Agrochemical producers rely on it as a key intermediate in herbicide and insecticide synthesis, particularly for pyridine-derived active ingredients. It is essential for large-scale crop protection manufacturing.

In food and flavor formulation, it contributes characteristic roasted and meaty notes to flavor systems at controlled concentrations under FEMA guidelines. This makes it a versatile tool for flavor chemists.

Home care and industrial cleaning product formulators use pyridine-based derivatives as biocidal actives in disinfectant and preservation systems. These applications ensure high standards of hygiene and safety.

Pyridine is supplied as a clear liquid in drums, IBCs, and bulk tanker quantities. Standard commercial grades include technical grade and pharmaceutical-grade meeting USP and BP specifications.

Buyers sourcing for regulated applications should confirm grade compliance with supplier documentation prior to procurement. Proper handling and storage are required to maintain the integrity of the chemical product.

Physical Properties

Melting Point	-41.6 °C
Boiling Point	115.2-115.3 °C
Density	0.98272 g/cm³ @ Temp: 20 °C
Flash Point	68 °F
Appearance	Pyridine is a colorless liquid. Nauseating, sickening fish-like odor. The Odor Threshold is 0.17 ppm.
Color	colorless
Odor	Nauseating odor detectable at 0.23 to 1.9 ppm (mean = 0.66 ppm)
Form	Liquid
Water Solubility	Miscible
Vapor Pressure	23.8 mm Hg ( 25 °C)
Refractive Index	n 20/D 1.509(lit.)
pH	8.81 (H2O, 20℃)
Log P	0.64 at 20℃

Safety & Handling

Danger GHS02 GHS07 GHS05 GHS08 GHS09 GHS06 Hazard Statements H225 Highly Flammable liquid and vapor H302 Harmful if swallowed H304 May be fatal if swallowed and enters airways H311 Toxic in contact with skin H312 Harmful in contact with skin H314 Causes severe skin burns and eye damage H315 Causes skin irritation H318 Causes serious eye damage H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation H336 May cause drowsiness or dizziness H351 Suspected of causing cancer H361 Suspected of damaging fertility or the unborn child H370 Causes damage to organs H372 Causes damage to organs through prolonged or repeated exposure H373 May causes damage to organs through prolonged or repeated exposure H400 Very toxic to aquatic life H410 Very toxic to aquatic life with long lasting effects Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P262 Do not get in eyes, on skin, or on clothing. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P318 IF exposed or concerned, get medical advice. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P331 Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P316 Get emergency medical help immediately. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P308+P316 Get emergency medical help immediately. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P362+P364 Take off contaminated clothing and wash it before reuse. P370+P378 Use … for extinction. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P403+P235 Store in a well-ventilated place. Keep cool. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code	29333100
UN Number	1282
ADR Class	3
Packing Group	II
Storage Class	3 - Flammable liquids
WGK (Germany)	2

Other Names

Industries

Pharmaceuticals & Healthcare Personal Care & Cosmetics Home Care & Industrial Cleaning Food & Nutrition